BLMH

Bleomycin hydrolase
PDB rendering based on 1cb5.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1cb5​, 2cb5​
Identifiers
Symbols	BLMH ; BH; BMH
External IDs	Template:OMIM5 Template:MGI HomoloGene: 330
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Bleomycin hydrolase, also known as BLMH, is a human gene.

Bleomycin hydrolase (BMH) is a cytoplasmic cysteine peptidase that is highly conserved through evolution; however, the only known activity of the enzyme is metabolic inactivation of the glycopeptide bleomycin (BLM), an essential component of combination chemotherapy regimens for cancer. The protein contains the signature active site residues of the cysteine protease papain superfamily.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. PMID 8125298.
• Ferrando AA, Velasco G, Campo E, Lopez-Otin C (1996). "Cloning and expression analysis of human bleomycin hydrolase, a cysteine proteinase involved in chemotherapy resistance". Cancer Res. 56 (8): 1746–50. PMID 8620487.CS1 maint: Multiple names: authors list (link)
• Brömme D, Rossi AB, Smeekens SP; et al. (1996). "Human bleomycin hydrolase: molecular cloning, sequencing, functional expression, and enzymatic characterization". Biochemistry. 35 (21): 6706–14. doi:10.1021/bi960092y. PMID 8639621.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Montoya SE, Ferrell RE, Lazo JS (1997). "Genomic structure and genetic mapping of the human neutral cysteine protease bleomycin hydrolase". Cancer Res. 57 (19): 4191–5. PMID 9331073.CS1 maint: Multiple names: authors list (link)
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. PMID 9373149.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ferrando AA, Pendás AM, Llano E; et al. (1998). "Gene characterization, promoter analysis, and chromosomal localization of human bleomycin hydrolase". J. Biol. Chem. 272 (52): 33298–304. PMID 9407121.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Koldamova RP, Lefterov IM, Gadjeva VG, Lazo JS (1998). "Essential binding and functional domains of human bleomycin hydrolase". Biochemistry. 37 (8): 2282–90. doi:10.1021/bi9722204. PMID 9485374.CS1 maint: Multiple names: authors list (link)
• Montoya SE, Aston CE, DeKosky ST; et al. (1998). "Bleomycin hydrolase is associated with risk of sporadic Alzheimer's disease". Nat. Genet. 18 (3): 211–2. doi:10.1038/ng0398-211. PMID 9500538.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zheng W, Johnston SA, Joshua-Tor L (1998). "The unusual active site of Gal6/bleomycin hydrolase can act as a carboxypeptidase, aminopeptidase, and peptide ligase". Cell. 93 (1): 103–9. PMID 9546396.CS1 maint: Multiple names: authors list (link)
• Koldamova RP, Lefterov IM, DiSabella MT, Lazo JS (1999). "An evolutionarily conserved cysteine protease, human bleomycin hydrolase, binds to the human homologue of ubiquitin-conjugating enzyme 9". Mol. Pharmacol. 54 (6): 954–61. PMID 9855622.CS1 maint: Multiple names: authors list (link)
• Takeda A, Nonaka M, Ishikawa A, Higuchi D (1999). "Immunohistochemical localization of the neutral cysteine protease bleomycin hydrolase in human skin". Arch. Dermatol. Res. 291 (4): 238–40. PMID 10335922.CS1 maint: Multiple names: authors list (link)
• Koldamova RP, Lefterov IM, DiSabella MT; et al. (1999). "Human bleomycin hydrolase binds ribosomal proteins". Biochemistry. 38 (22): 7111–7. doi:10.1021/bi990135l. PMID 10353821.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• O'Farrell PA, Gonzalez F, Zheng W; et al. (1999). "Crystal structure of human bleomycin hydrolase, a self-compartmentalizing cysteine protease". Structure. 7 (6): 619–27. PMID 10404591.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Malherbe P, Faull RL, Richards JG (2000). "Regional and cellular distribution of bleomycin hydrolase mRNA in human brain: comparison between Alzheimer's diseased and control brains". Neurosci. Lett. 281 (1): 37–40. PMID 10686410.CS1 maint: Multiple names: authors list (link)
• Lefterov IM, Koldamova RP, Lazo JS (2000). "Human bleomycin hydrolase regulates the secretion of amyloid precursor protein". FASEB J. 14 (12): 1837–47. PMID 10973933.CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nivet-Antoine V, Coulhon MP, Le Denmat C; et al. (2003). "[Apolipoprotein E and bleomycin hydrolase. Polymorphisms: association with neurodegenerative diseases]". Ann. Biol. Clin. (Paris). 61 (1): 61–7. PMID 12604387.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)