BMP5 (gene)

Bone morphogenetic protein 5
Identifiers
Symbols	BMP5 ; MGC34244
External IDs	Template:OMIM5 Template:MGI HomoloGene: 22412
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Bone morphogenetic protein 5, also known as BMP5, is a human gene.

This gene encodes a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. The superfamily includes large families of growth and differentiation factors. Bone morphogenetic proteins were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. These proteins are synthesized as prepropeptides, cleaved, and then processed into dimeric proteins. This protein may act as an important signaling molecule within the trabecular meshwork and optic nerve head, and may play a potential role in glaucoma pathogenesis. This gene is differentially regulated during the formation of various tumors.

Further reading

• Hahn GV, Cohen RB, Wozney JM; et al. (1992). "A bone morphogenetic protein subfamily: chromosomal localization of human genes for BMP5, BMP6, and BMP7". Genomics. 14 (3): 759–62. PMID 1427904.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Celeste AJ, Iannazzi JA, Taylor RC; et al. (1991). "Identification of transforming growth factor beta family members present in bone-inductive protein purified from bovine bone". Proc. Natl. Acad. Sci. U.S.A. 87 (24): 9843–7. PMID 2263636.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sakaue M, Kitazawa S, Nishida K; et al. (1996). "Molecular cloning and characterization of human bone morphogenic protein (BMP)-5 gene promoter". Biochem. Biophys. Res. Commun. 221 (3): 768–72. doi:10.1006/bbrc.1996.0671. PMID 8630036.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• You L, Kruse FE, Pohl J, Völcker HE (1999). "Bone morphogenetic proteins and growth and differentiation factors in the human cornea". Invest. Ophthalmol. Vis. Sci. 40 (2): 296–311. PMID 9950587.CS1 maint: Multiple names: authors list (link)
• Imai N, Iwai A, Hatakeyama S; et al. (2001). "Expression of bone morphogenetic proteins in colon carcinoma with heterotopic ossification". Pathol. Int. 51 (8): 643–8. PMID 11564221.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Beck HN, Drahushuk K, Jacoby DB; et al. (2003). "Bone morphogenetic protein-5 (BMP-5) promotes dendritic growth in cultured sympathetic neurons". BMC neuroscience. 2: 12. PMID 11580864.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Jin Y, Lu HB, Liong E; et al. (2002). "Transcriptional mRNA of BMP-2, 3, 4 and 5 in trigeminal nerve, benign and malignant peripheral nerve sheath tumors". Histol. Histopathol. 16 (4): 1013–9. PMID 11642720.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Cohen A, Mulas R, Seri M; et al. (2002). "Meier-Gorlin syndrome (ear-patella-short stature syndrome) in an Italian patient: clinical evaluation and analysis of possible candidate genes". Am. J. Med. Genet. 107 (1): 48–51. PMID 11807867.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Jiang FX, Stanley EG, Gonez LJ, Harrison LC (2002). "Bone morphogenetic proteins promote development of fetal pancreas epithelial colonies containing insulin-positive cells". J. Cell. Sci. 115 (Pt 4): 753–60. PMID 11865031.CS1 maint: Multiple names: authors list (link)
• Luo J, Dunn T, Ewing C; et al. (2002). "Gene expression signature of benign prostatic hyperplasia revealed by cDNA microarray analysis". Prostate. 51 (3): 189–200. doi:10.1002/pros.10087. PMID 11967953.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wordinger RJ, Agarwal R, Talati M; et al. (2002). "Expression of bone morphogenetic proteins (BMP), BMP receptors, and BMP associated proteins in human trabecular meshwork and optic nerve head cells and tissues". Mol. Vis. 8: 241–50. PMID 12131877.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mungall AJ, Palmer SA, Sims SK; et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nakayama N, Han CY, Cam L; et al. (2004). "A novel chordin-like BMP inhibitor, CHL2, expressed preferentially in chondrocytes of developing cartilage and osteoarthritic joint cartilage". Development. 131 (1): 229–40. doi:10.1242/dev.00901. PMID 14660436.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Xu WP, Shiba H, Mizuno N; et al. (2005). "Effect of bone morphogenetic proteins-4, -5 and -6 on DNA synthesis and expression of bone-related proteins in cultured human periodontal ligament cells". Cell Biol. Int. 28 (10): 675–82. doi:10.1016/j.cellbi.2004.06.004. PMID 15516325.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bobinac D, Marić I, Zoricić S; et al. (2005). "Expression of bone morphogenetic proteins in human metastatic prostate and breast cancer". Croat. Med. J. 46 (3): 389–96. PMID 15861517.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bramlage CP, Häupl T, Kaps C; et al. (2006). "Decrease in expression of bone morphogenetic proteins 4 and 5 in synovial tissue of patients with osteoarthritis and rheumatoid arthritis". Arthritis Res. Ther. 8 (3): R58. doi:10.1186/ar1923. PMID 16542506.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wilkins JM, Southam L, Price AJ; et al. (2007). "Extreme context specificity in differential allelic expression". Hum. Mol. Genet. 16 (5): 537–46. doi:10.1093/hmg/ddl488. PMID 17220169.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)