BMP6 (gene)

Bone morphogenetic protein 6
Identifiers
Symbols	BMP6 ; VGR; VGR1
External IDs	Template:OMIM5 Template:MGI HomoloGene: 1300
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Bone morphogenetic protein 6, also known as BMP6, is a human gene.

The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, the BMP encoded by this gene has a proposed role in early development. In addition, the fact that this BMP is closely related to BMP5 and BMP7 has led to speculation of possible bone inductive activity.

Further reading

• Hahn GV, Cohen RB, Wozney JM; et al. (1992). "A bone morphogenetic protein subfamily: chromosomal localization of human genes for BMP5, BMP6, and BMP7". Genomics. 14 (3): 759–62. PMID 1427904.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sauermann U, Meyermann R, Schluesener HJ (1993). "Cloning of a novel TGF-beta related cytokine, the vgr, from rat brain: cloning of and comparison to homologous human cytokines". J. Neurosci. Res. 33 (1): 142–7. doi:10.1002/jnr.490330118. PMID 1453478.CS1 maint: Multiple names: authors list (link)
• Celeste AJ, Iannazzi JA, Taylor RC; et al. (1991). "Identification of transforming growth factor beta family members present in bone-inductive protein purified from bovine bone". Proc. Natl. Acad. Sci. U.S.A. 87 (24): 9843–7. PMID 2263636.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Schluesener HJ, Meyermann R (1995). "Immunolocalization of BMP-6, a novel TGF-beta-related cytokine, in normal and atherosclerotic smooth muscle cells". Atherosclerosis. 113 (2): 153–6. PMID 7605353.
• Gitelman SE, Kobrin MS, Ye JQ; et al. (1994). "Recombinant Vgr-1/BMP-6-expressing tumors induce fibrosis and endochondral bone formation in vivo". J. Cell Biol. 126 (6): 1595–609. PMID 8089189.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Barnes J, Anthony CT, Wall N, Steiner MS (1997). "Bone morphogenetic protein-6 expression in normal and malignant prostate". World journal of urology. 13 (6): 337–43. PMID 9116752.CS1 maint: Multiple names: authors list (link)
• Hamdy FC, Autzen P, Robinson MC; et al. (1997). "Immunolocalization and messenger RNA expression of bone morphogenetic protein-6 in human benign and malignant prostatic tissue". Cancer Res. 57 (19): 4427–31. PMID 9331107.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Olavesen MG, Bentley E, Mason RV; et al. (1998). "Fine mapping of 39 ESTs on human chromosome 6p23-p25". Genomics. 46 (2): 303–6. doi:10.1006/geno.1997.5032. PMID 9417921.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rickard DJ, Hofbauer LC, Bonde SK; et al. (1998). "Bone morphogenetic protein-6 production in human osteoblastic cell lines. Selective regulation by estrogen". J. Clin. Invest. 101 (2): 413–22. PMID 9435314.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tamada H, Kitazawa R, Gohji K; et al. (1998). "Molecular cloning and analysis of the 5'-flanking region of the human bone morphogenetic protein-6 (BMP-6)". Biochim. Biophys. Acta. 1395 (3): 247–51. PMID 9512655.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ebisawa T, Tada K, Kitajima I; et al. (2000). "Characterization of bone morphogenetic protein-6 signaling pathways in osteoblast differentiation". J. Cell. Sci. 112 ( Pt 20): 3519–27. PMID 10504300.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Heikinheimo KA, Laine MA, Ritvos OV; et al. (1999). "Bone morphogenetic protein-6 is a marker of serous acinar cell differentiation in normal and neoplastic human salivary gland". Cancer Res. 59 (22): 5815–21. PMID 10582704.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ahmed N, Sammons J, Carson RJ; et al. (2001). "Effect of bone morphogenetic protein-6 on haemopoietic stem cells and cytokine production in normal human bone marrow stroma". Cell Biol. Int. 25 (5): 429–35. doi:10.1006/cbir.2000.0662. PMID 11401330.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Shimizu M, Higuchi K, Kasai S; et al. (2003). "A congenic mouse and candidate gene at the Chromosome 13 locus regulating bone density". Mamm. Genome. 13 (7): 335–40. doi:10.1007/s00335-001-2129-4. PMID 12140680.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Moser M, Binder O, Wu Y; et al. (2003). "BMPER, a novel endothelial cell precursor-derived protein, antagonizes bone morphogenetic protein signaling and endothelial cell differentiation". Mol. Cell. Biol. 23 (16): 5664–79. PMID 12897139.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bobacz K, Gruber R, Soleiman A; et al. (2003). "Expression of bone morphogenetic protein 6 in healthy and osteoarthritic human articular chondrocytes and stimulation of matrix synthesis in vitro". Arthritis Rheum. 48 (9): 2501–8. doi:10.1002/art.11248. PMID 13130469.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lories RJ, Derese I, Ceuppens JL, Luyten FP (2003). "Bone morphogenetic proteins 2 and 6, expressed in arthritic synovium, are regulated by proinflammatory cytokines and differentially modulate fibroblast-like synoviocyte apoptosis". Arthritis Rheum. 48 (10): 2807–18. doi:10.1002/art.11389. PMID 14558086.CS1 maint: Multiple names: authors list (link)
• Mungall AJ, Palmer SA, Sims SK; et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Laurikkala J, Kassai Y, Pakkasjärvi L; et al. (2004). "Identification of a secreted BMP antagonist, ectodin, integrating BMP, FGF, and SHH signals from the tooth enamel knot". Dev. Biol. 264 (1): 91–105. PMID 14623234.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)