BRMS1

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
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RefSeq (mRNA)

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RefSeq (protein)

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Breast cancer metastasis suppressor 1 is a protein that in humans is encoded by the BRMS1 gene.[1][2]

This gene reduces the metastatic potential, but not the tumorogenicity, of human breast cancer and melanoma cell lines.[3] The protein encoded by this gene localizes primarily to the nucleus, and is a component of the mSin3a family of histone deacetylase complexes (HDAC). The protein contains two coiled-coil motifs and several imperfect leucine zipper motifs. Alternative splicing results in two transcript variants encoding different isoforms.[2]

References

  1. Seraj MJ, Samant RS, Verderame MF, Welch DR (Jun 2000). "Functional evidence for a novel human breast carcinoma metastasis suppressor, BRMS1, encoded at chromosome 11q13". Cancer Research. 60 (11): 2764–9. PMID 10850410.
  2. 2.0 2.1 "Entrez Gene: BRMS1 breast cancer metastasis suppressor 1".
  3. Penn State Researchers Find Breast Cancer Metastasis Suppressor Gene

External links

Further reading