Behçet's disease medical therapy
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Hamid Qazi, MD, BSc [2]
Overview
Current treatment is aimed at easing the symptoms, reducing inflammation, and controlling the immune system. Anti-TNF therapy, such as infliximab, has shown promise in treating the uveitis associated with the disease. Another Anti-TNF agent, etanercept, may be useful in patients with mainly skin and mucosal symptoms. Interferon alfa-2a, azathioprine, colchicine, thalidomide, dapsone and rebamipide are among other agents that are used alternatives.
Medical Therapy
- Current treatment is aimed at easing the symptoms, reducing inflammation, and controlling the immune system.
- Anti-TNF therapy such as infliximab has shown promise in treating the uveitis associated with the disease.[1][2]
- Another Anti-TNF agent, etanercept, may be useful in patients with mainly skin and mucosal symptoms.[3]
- Interferon alfa-2a may also be an effective alternative treatment, particularly for patients with genital and oral ulcers as well as with ocular lesions.[4][5]
- Azathioprine, when used in combination with interferon alfa-2b also shows promise and colchicine may also be useful for treating some genital ulcers, erythema nodosum, and arthritis.[6][7]
- Thalidomide has been used due to its immune-modifying effect.[8]
- Dapsone and rebamipide have been shown, in small studies, to have beneficial results for mucocutaneous lesions.[9][10]
References
- ↑ Sfikakis PP, Theodossiadis PG, Katsiari CG, Kaklamanis P, Markomichelakis NN (2001). "Effect of infliximab on sight-threatening panuveitis in Behçet's disease". Lancet. 358 (9278): 295–6. PMID 11498218.
- ↑ Sfikakis PP (2002). "Behçet's disease: a new target for anti-tumour necrosis factor treatment". Ann Rheum Dis. 61 Suppl 2: ii51–3. PMC 1766720. PMID 12379622.
- ↑ Melikoglu M, Fresko I, Mat C, Ozyazgan Y, Gogus F, Yurdakul S; et al. (2005). "Short-term trial of etanercept in Behçet's disease: a double blind, placebo controlled study". J Rheumatol. 32 (1): 98–105. PMID 15630733.
- ↑ Alpsoy E, Durusoy C, Yilmaz E, Ozgurel Y, Ermis O, Yazar S; et al. (2002). "Interferon alfa-2a in the treatment of Behçet disease: a randomized placebo-controlled and double-blind study". Arch Dermatol. 138 (4): 467–71. PMID 11939808.
- ↑ Kötter I, Zierhut M, Eckstein AK, Vonthein R, Ness T, Günaydin I; et al. (2003). "Human recombinant interferon alfa-2a for the treatment of Behçet's disease with sight threatening posterior or panuveitis". Br J Ophthalmol. 87 (4): 423–31. PMC 1771623. PMID 12642304.
- ↑ Hamuryudan V, Ozyazgan Y, Fresko Y, Mat C, Yurdakul S, Yazici H (2002). "Interferon alfa combined with azathioprine for the uveitis of Behçet's disease: an open study". Isr Med Assoc J. 4 (11 Suppl): 928–30. PMID 12455182.
- ↑ Yurdakul S, Mat C, Tuzun Y, Ozyazgan Y, Hamuryudan V, Uysal O, Senocak M, Yazici H (2001). "A double-blind trial of colchicine in Behçet's syndrome". Arthritis Rheum. 44 (11): 2686–92. PMID 11710724.
- ↑ Hamuryudan V, Mat C, Saip S, Ozyazgan Y, Siva A, Yurdakul S, Zwingenberger K, Yazici H (1998). "Thalidomide in the treatment of the mucocutaneous lesions of the Behcet syndrome.
A randomized, double-blind, placebo-controlled trial". Ann Intern Med. 128 (6): 443–50. PMID 9499327. line feed character in
|title=at position 83 (help) - ↑ Matsuda T, Ohno S, Hirohata S, Miyanaga Y, Ujihara H, Inaba G, Nakamura S, Tanaka S, Kogure M, Mizushima Y (2003). "Efficacy of rebamipide as adjunctive therapy in the treatment of recurrent oral aphthous ulcers in patients with Behçet's disease: a randomised, double-blind, placebo-controlled study". Drugs R D. 4 (1): 19–28. PMID 12568631.
- ↑ Sharquie KE, Najim RA, Abu-Raghif AR (2002). "Dapsone in Behçet's disease: a double-blind, placebo-controlled, cross-over study". J Dermatol. 29 (5): 267–79. PMID 12081158.