Beta-thalassemia differential diagnosis
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Maryam Hadipour, M.D.[2]
Overview
Beta-thalassemia may have similar features of other conditions such as iron deficiency anemia, sideroblastic anemia, Alpha-thalassemia, other hemolytic anemia and other hemoglobinopathies including sickle cell anemia. To differentiate these conditions, history and physical examination, electrophoresis of hemoglobin, DNA analysis and iron level assessments would be useful.
Beta-thalassemia differential diagnosis
Beta-thalassemia disease symptoms are having a wide range and can be similar to various other diseases such as[1][2]:
- Iron deficiency anemia
- Sideroblastic anemia
- Alpha-thalassemia
- Sickle cell anemia
- Hemolytic anemia
- Other hemoglobinopathies and other causes of chronic anemia
However, the diagnosis and differentiation would be properly performed thorough history and physical examination, electrophoresis of hemoglobin, DNA analysis and iron level assessments.
References
- ↑ Forget BG (March 1993). "The pathophysiology and molecular genetics of beta thalassemia". Mt Sinai J Med. 60 (2): 95–103. PMID 8469250.
- ↑ Fibach E, Rachmilewitz EA (2017). "Pathophysiology and treatment of patients with beta-thalassemia - an update". F1000Res. 6: 2156. doi:10.12688/f1000research.12688.1. PMC 5749127. PMID 29333256.