Bromodeoxyuridine
|
WikiDoc Resources for Bromodeoxyuridine |
|
Articles |
|---|
|
Most recent articles on Bromodeoxyuridine Most cited articles on Bromodeoxyuridine |
|
Media |
|
Powerpoint slides on Bromodeoxyuridine |
|
Evidence Based Medicine |
|
Cochrane Collaboration on Bromodeoxyuridine |
|
Clinical Trials |
|
Ongoing Trials on Bromodeoxyuridine at Clinical Trials.gov Trial results on Bromodeoxyuridine Clinical Trials on Bromodeoxyuridine at Google
|
|
Guidelines / Policies / Govt |
|
US National Guidelines Clearinghouse on Bromodeoxyuridine NICE Guidance on Bromodeoxyuridine
|
|
Books |
|
News |
|
Commentary |
|
Definitions |
|
Patient Resources / Community |
|
Patient resources on Bromodeoxyuridine Discussion groups on Bromodeoxyuridine Patient Handouts on Bromodeoxyuridine Directions to Hospitals Treating Bromodeoxyuridine Risk calculators and risk factors for Bromodeoxyuridine
|
|
Healthcare Provider Resources |
|
Causes & Risk Factors for Bromodeoxyuridine |
|
Continuing Medical Education (CME) |
|
International |
|
|
|
Business |
|
Experimental / Informatics |
Bromodeoxyuridine (5-bromo-2-deoxyuridine, BrdU) is a synthetic nucleoside which is an analogue of thymidine. BrdU is commonly used in the detection of proliferating cells in living tissues.
BrdU can be incorporated into the newly synthesized DNA of replicating cells (during the S phase of the cell cycle), substituting for thymidine during DNA replication. Antibodies specific for BrdU can then be used to detect the incorporated chemical (see immunohistochemistry), thus indicating cells that were actively replicating their DNA. Binding of the antibody requires denaturation of the DNA, usually by exposing the cells to acid or heat.
Because BrdU can replace thymidine during DNA replication, it can cause mutations, and its use is therefore potentially a health hazard.
See also
External links
- BrdU incorporation during DNA replication - Jiayang Chien, Wellesley College