C-c motif chemokine ligand 27

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Identifiers
Aliases
External IDs	GeneCards: [1]
Orthologs
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a
Wikidata
View/Edit Human

C-C motif chemokine ligand 27 is a protein that in humans is encoded by the CCL27 gene.

Function

This gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The protein encoded by this gene is chemotactic for skin-associated memory T lymphocytes. This cytokine may also play a role in mediating homing of lymphocytes to cutaneous sites. It specifically binds to chemokine receptor 10 (CCR10). Studies of a similar murine protein indicate that these protein-receptor interactions have a pivotal role in T cell-mediated skin inflammation. [provided by RefSeq, Sep 2014].

Further reading

• Mackay CR (February 2002). "New avenues for anti-inflammatory therapy". Nat. Med. 8 (2): 117–8. doi:10.1038/nm0202-117. PMID 11821893.
• Homey B, Alenius H, Müller A, Soto H, Bowman EP, Yuan W, McEvoy L, Lauerma AI, Assmann T, Bünemann E, Lehto M, Wolff H, Yen D, Marxhausen H, To W, Sedgwick J, Ruzicka T, Lehmann P, Zlotnik A (February 2002). "CCL27-CCR10 interactions regulate T cell-mediated skin inflammation". Nat. Med. 8 (2): 157–65. doi:10.1038/nm0202-157. PMID 11821900.
• Kakinuma T, Saeki H, Tsunemi Y, Fujita H, Asano N, Mitsui H, Tada Y, Wakugawa M, Watanabe T, Torii H, Komine M, Asahina A, Nakamura K, Tamaki K (March 2003). "Increased serum cutaneous T cell-attracting chemokine (CCL27) levels in patients with atopic dermatitis and psoriasis vulgaris". J. Allergy Clin. Immunol. 111 (3): 592–7. PMID 12642842.
• Hijnen D, De Bruin-Weller M, Oosting B, Lebre C, De Jong E, Bruijnzeel-Koomen C, Knol E (February 2004). "Serum thymus and activation-regulated chemokine (TARC) and cutaneous T cell- attracting chemokine (CTACK) levels in allergic diseases: TARC and CTACK are disease-specific markers for atopic dermatitis". J. Allergy Clin. Immunol. 113 (2): 334–40. doi:10.1016/j.jaci.2003.12.007. PMID 14767451.
• Vestergaard C, Johansen C, Christensen U, Just H, Hohwy T, Deleuran M (September 2004). "TARC augments TNF-alpha-induced CTACK production in keratinocytes". Exp. Dermatol. 13 (9): 551–7. doi:10.1111/j.0906-6705.2004.00202.x. PMID 15335355.
• Hirata T, Furukawa Y, Yang BG, Hieshima K, Fukuda M, Kannagi R, Yoshie O, Miyasaka M (December 2004). "Human P-selectin glycoprotein ligand-1 (PSGL-1) interacts with the skin-associated chemokine CCL27 via sulfated tyrosines at the PSGL-1 amino terminus". J. Biol. Chem. 279 (50): 51775–82. doi:10.1074/jbc.M409868200. PMID 15466853.
• Vestergaard C, Johansen C, Otkjaer K, Deleuran M, Iversen L (January 2005). "Tumor necrosis factor-alpha-induced CTACK/CCL27 (cutaneous T-cell-attracting chemokine) production in keratinocytes is controlled by nuclear factor kappaB". Cytokine. 29 (2): 49–55. doi:10.1016/j.cyto.2004.09.008. PMID 15598438.
• Spiekstra SW, Toebak MJ, Sampat-Sardjoepersad S, van Beek PJ, Boorsma DM, Stoof TJ, von Blomberg BM, Scheper RJ, Bruynzeel DP, Rustemeyer T, Gibbs S (February 2005). "Induction of cytokine (interleukin-1alpha and tumor necrosis factor-alpha) and chemokine (CCL20, CCL27, and CXCL8) alarm signals after allergen and irritant exposure". Exp. Dermatol. 14 (2): 109–16. doi:10.1111/j.0906-6705.2005.00226.x. PMID 15679580.
• Kagami S, Saeki H, Komine M, Kakinuma T, Nakamura K, Tsunemi Y, Sasaki K, Asahina A, Tamaki K (February 2006). "CCL28 production in HaCaT cells was mediated by different signal pathways from CCL27". Exp. Dermatol. 15 (2): 95–100. doi:10.1111/j.1600-0625.2005.00390.x. PMID 16433680.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.