CA4

Carbonic anhydrase IV
PDB rendering based on 1znc.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1znc​
Identifiers
Symbols	CA4 ; CAIV; Car4; RP17
External IDs	Template:OMIM5 Template:MGI HomoloGene: 20183
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Carbonic anhydrase IV, also known as CA4, is a human gene.

Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA IV is a glycosylphosphatidyl-inositol-anchored membrane isozyme expressed on the luminal surfaces of pulmonary (and certain other) capillaries and of proximal renal tubules. Its exact function is not known, however, it may have a role in inherited renal abnormalities of bicarbonate transport.

Further reading

• Okuyama T, Sato S, Zhu XL; et al. (1992). "Human carbonic anhydrase IV: cDNA cloning, sequence comparison, and expression in COS cell membranes". Proc. Natl. Acad. Sci. U.S.A. 89 (4): 1315–9. PMID 1311094.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hageman GS, Zhu XL, Waheed A, Sly WS (1991). "Localization of carbonic anhydrase IV in a specific capillary bed of the human eye". Proc. Natl. Acad. Sci. U.S.A. 88 (7): 2716–20. PMID 1901414.CS1 maint: Multiple names: authors list (link)
• Zhu XL, Sly WS (1990). "Carbonic anhydrase IV from human lung. Purification, characterization, and comparison with membrane carbonic anhydrase from human kidney". J. Biol. Chem. 265 (15): 8795–801. PMID 2111324.
• Carter ND, Fryer A, Grant AG; et al. (1990). "Membrane specific carbonic anhydrase (CAIV) expression in human tissues". Biochim. Biophys. Acta. 1026 (1): 113–6. PMID 2116168.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Whitney PL, Briggle TV (1982). "Membrane-associated carbonic anhydrase purified from bovine lung". J. Biol. Chem. 257 (20): 12056–9. PMID 6811592.
• Bardien S, Ebenezer N, Greenberg J; et al. (1995). "An eighth locus for autosomal dominant retinitis pigmentosa is linked to chromosome 17q". Hum. Mol. Genet. 4 (8): 1459–62. PMID 7581389.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Okuyama T, Waheed A, Kusumoto W; et al. (1995). "Carbonic anhydrase IV: role of removal of C-terminal domain in glycosylphosphatidylinositol anchoring and realization of enzyme activity". Arch. Biochem. Biophys. 320 (2): 315–22. PMID 7625839.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mahieu I, Benjamin A, Stephens R; et al. (1995). "Characterization of membrane bound carbonic anhydrase IV (CA IV) located on the external surface of lung pulmonary endothelial cells". Biochem. Soc. Trans. 23 (2): 320S. PMID 7672351.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sender S, Gros G, Waheed A; et al. (1994). "Immunohistochemical localization of carbonic anhydrase IV in capillaries of rat and human skeletal muscle". J. Histochem. Cytochem. 42 (9): 1229–36. PMID 8064130.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Okuyama T, Batanian JR, Sly WS (1993). "Genomic organization and localization of gene for human carbonic anhydrase IV to chromosome 17q". Genomics. 16 (3): 678–84. doi:10.1006/geno.1993.1247. PMID 8325641.CS1 maint: Multiple names: authors list (link)
• Fleming RE, Parkkila S, Parkkila AK; et al. (1996). "Carbonic anhydrase IV expression in rat and human gastrointestinal tract regional, cellular, and subcellular localization". J. Clin. Invest. 96 (6): 2907–13. PMID 8675662.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Waheed A, Okuyama T, Heyduk T, Sly WS (1996). "Carbonic anhydrase IV: purification of a secretory form of the recombinant human enzyme and identification of the positions and importance of its disulfide bonds". Arch. Biochem. Biophys. 333 (2): 432–8. doi:10.1006/abbi.1996.0412. PMID 8809084.CS1 maint: Multiple names: authors list (link)
• Parkkila S, Parkkila AK, Juvonen T; et al. (1996). "Membrane-bound carbonic anhydrase IV is expressed in the luminal plasma membrane of the human gallbladder epithelium". Hepatology. 24 (5): 1104–8. doi:10.1002/hep.510240521. PMID 8903383.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Stams T, Nair SK, Okuyama T; et al. (1997). "Crystal structure of the secretory form of membrane-associated human carbonic anhydrase IV at 2.8-A resolution". Proc. Natl. Acad. Sci. U.S.A. 93 (24): 13589–94. PMID 8942978.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bardien S, Ramesar R, Bhattacharya S, Greenberg J (1997). "Retinitis pigmentosa locus on 17q (RP17): fine localization to 17q22 and exclusion of the PDEG and TIMP2 genes". Hum. Genet. 101 (1): 13–7. PMID 9385361.CS1 maint: Multiple names: authors list (link)
• Sender S, Decker B, Fenske CD; et al. (1998). "Localization of carbonic anhydrase IV in rat and human heart muscle". J. Histochem. Cytochem. 46 (7): 855–61. PMID 9632745.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wistrand PJ, Carter ND, Conroy CW, Mahieu I (1999). "Carbonic anhydrase IV activity is localized on the exterior surface of human erythrocytes". Acta Physiol. Scand. 165 (2): 211–8. PMID 10090333.CS1 maint: Multiple names: authors list (link)
• Fujikawa-Adachi K, Nishimori I, Sakamoto S; et al. (1999). "Identification of carbonic anhydrase IV and VI mRNA expression in human pancreas and salivary glands". Pancreas. 18 (4): 329–35. PMID 10231836.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sterling D, Alvarez BV, Casey JR (2002). "The extracellular component of a transport metabolon. Extracellular loop 4 of the human AE1 Cl-/HCO3- exchanger binds carbonic anhydrase IV". J. Biol. Chem. 277 (28): 25239–46. doi:10.1074/jbc.M202562200. PMID 11994299.CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)