CCNT2

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Cyclin T2
PDB rendering based on 2ivx.
Available structures
PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB
Identifiers
Symbols CCNT2 ; FLJ90560; MGC134840
External IDs Template:OMIM5 Template:MGI HomoloGene: 14043
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species Human Mouse
Entrez n/a n/a
Ensembl n/a n/a
UniProt n/a n/a
RefSeq (mRNA) n/a n/a
RefSeq (protein) n/a n/a
Location (UCSC) n/a n/a
PubMed search n/a n/a

Cyclin T2, also known as CCNT2, is a human gene.[1]

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin and its kinase partner CDK9 were found to be subunits of the transcription elongation factor p-TEFb. The p-TEFb complex containing this cyclin was reported to interact with, and act as a negative regulator of human immunodeficiency virus type 1 (HIV-1) Tat protein. Two alternatively spliced transcript variants, which encode distinct isoforms, have been described.[1]

References

  1. ↑ 1.0 1.1 "Entrez Gene: CCNT2 cyclin T2".

Further reading

  • Wolff A (1976). "[Problem of occupational disability hazards]". Lebensversicherungs Medizin. 28 (3): 76–7. PMID 9544.
  • Peng J, Zhu Y, Milton JT, Price DH (1998). "Identification of multiple cyclin subunits of human P-TEFb". Genes Dev. 12 (5): 755–62. PMID 9499409.
  • Wimmer J, Fujinaga K, Taube R; et al. (1999). "Interactions between Tat and TAR and human immunodeficiency virus replication are facilitated by human cyclin T1 but not cyclins T2a or T2b". Virology. 255 (1): 182–9. doi:10.1006/viro.1998.9589. PMID 10049833.
  • Kwak YT, Ivanov D, Guo J; et al. (1999). "Role of the human and murine cyclin T proteins in regulating HIV-1 tat-activation". J. Mol. Biol. 288 (1): 57–69. doi:10.1006/jmbi.1999.2664. PMID 10329126.
  • Bieniasz PD, Grdina TA, Bogerd HP, Cullen BR (1999). "Analysis of the effect of natural sequence variation in Tat and in cyclin T on the formation and RNA binding properties of Tat-cyclin T complexes". J. Virol. 73 (7): 5777–86. PMID 10364329.
  • Napolitano G, Licciardo P, Gallo P; et al. (1999). "The CDK9-associated cyclins T1 and T2 exert opposite effects on HIV-1 Tat activity". AIDS. 13 (12): 1453–9. PMID 10465067.
  • Herrmann CH, Mancini MA (2001). "The Cdk9 and cyclin T subunits of TAK/P-TEFb localize to splicing factor-rich nuclear speckle regions". J. Cell. Sci. 114 (Pt 8): 1491–503. PMID 11282025.
  • Nguyen VT, Kiss T, Michels AA, Bensaude O (2001). "7SK small nuclear RNA binds to and inhibits the activity of CDK9/cyclin T complexes". Nature. 414 (6861): 322–5. doi:10.1038/35104581. PMID 11713533.
  • Tolstonog GV, Mothes E, Shoeman RL, Traub P (2002). "Isolation of SDS-stable complexes of the intermediate filament protein vimentin with repetitive, mobile, nuclear matrix attachment region, and mitochondrial DNA sequence elements from cultured mouse and human fibroblasts". DNA Cell Biol. 20 (9): 531–54. doi:10.1089/104454901317094954. PMID 11747605.
  • Simone C, Bagella L, Bellan C, Giordano A (2002). "Physical interaction between pRb and cdk9/cyclinT2 complex". Oncogene. 21 (26): 4158–65. doi:10.1038/sj.onc.1205511. PMID 12037672.
  • Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
  • Michels AA, Nguyen VT, Fraldi A; et al. (2003). "MAQ1 and 7SK RNA interact with CDK9/cyclin T complexes in a transcription-dependent manner". Mol. Cell. Biol. 23 (14): 4859–69. PMID 12832472.
  • Beausoleil SA, Jedrychowski M, Schwartz D; et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMID 15302935.
  • Kurosu T, Zhang F, Peterlin BM (2005). "Transcriptional activity and substrate recognition of cyclin T2 from P-TEFb". Gene. 343 (1): 173–9. doi:10.1016/j.gene.2004.08.027. PMID 15563843.
  • Hillier LW, Graves TA, Fulton RS; et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.
  • Jang MK, Mochizuki K, Zhou M; et al. (2005). "The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNA polymerase II-dependent transcription". Mol. Cell. 19 (4): 523–34. doi:10.1016/j.molcel.2005.06.027. PMID 16109376.
  • Cottone G, Baldi A, Palescandolo E; et al. (2006). "Pkn is a novel partner of cyclin T2a in muscle differentiation". J. Cell. Physiol. 207 (1): 232–7. doi:10.1002/jcp.20566. PMID 16331689.
  • Simone C, Giordano A (2007). "Abrogation of signal-dependent activation of the cdk9/cyclin T2a complex in human RD rhabdomyosarcoma cells". Cell Death Differ. 14 (1): 192–5. doi:10.1038/sj.cdd.4402008. PMID 16841087.
  • Fu J, Yoon HG, Qin J, Wong J (2007). "Regulation of P-TEFb elongation complex activity by CDK9 acetylation". Mol. Cell. Biol. 27 (13): 4641–51. doi:10.1128/MCB.00857-06. PMID 17452463.

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