CMRF35-like molecule 1 is a protein that in humans is encoded by the CD300LFgene.[1][2]
CD300LF is an inhibitory receptor of the Ig superfamily expressed on myeloid cells. It mediates negative regulatory signals by recruiting SHP1 (PTPN6; MIM 176883) or SHIP (INPP5D; MIM 601582) (Sui et al., 2004; Alvarez-Errico et al., 2004).[supplied by OMIM][2]
Chung DH, Humphrey MB, Nakamura MC, et al. (2004). "CMRF-35-like molecule-1, a novel mouse myeloid receptor, can inhibit osteoclast formation". J. Immunol. 171 (12): 6541–8. doi:10.4049/jimmunol.171.12.6541. PMID14662855.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID14702039.
Sui L, Li N, Liu Q, et al. (2004). "IgSF13, a novel human inhibitory receptor of the immunoglobulin superfamily, is preferentially expressed in dendritic cells and monocytes". Biochem. Biophys. Res. Commun. 319 (3): 920–8. doi:10.1016/j.bbrc.2004.05.065. PMID15184070.
Alvarez-Errico D, Aguilar H, Kitzig F, et al. (2005). "IREM-1 is a novel inhibitory receptor expressed by myeloid cells". Eur. J. Immunol. 34 (12): 3690–701. doi:10.1002/eji.200425433. PMID15549731.
Alvarez-Errico D, Sayós J, López-Botet M (2007). "The IREM-1 (CD300f) inhibitory receptor associates with the p85alpha subunit of phosphoinositide 3-kinase". J. Immunol. 178 (2): 808–16. doi:10.4049/jimmunol.178.2.808. PMID17202342.
