CDA (gene)

Cytidine deaminase
PDB rendering based on 1mq0.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1mq0​
Identifiers
Symbols	CDA ; CDD
External IDs	Template:OMIM5 Template:MGI HomoloGene: 1352
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Cytidine deaminase, also known as CDA, is a human gene.

This gene encodes an enzyme involved in pyrimidine salvaging. The encoded protein forms a homotetramer that catalyzes the irreversible hydrolytic deamination of cytidine and deoxycytidine to uridine and deoxyuridine, respectively. It is one of several deaminases responsible for maintaining the cellular pyrimidine pool. Mutations in this gene are associated with decreased sensitivity to the cytosine nucleoside analogue cytosine arabinoside used in the treatment of certain childhood leukemias.

Further reading

• Wentworth DF, Wolfenden R (1976). "On the interaction of 3,4,5,6-tetrahydrouridine with human liver cytidine deaminase". Biochemistry. 14 (23): 5099–105. PMID 53069.
• Laliberté J, Momparler RL (1994). "Human cytidine deaminase: purification of enzyme, cloning, and expression of its complementary DNA". Cancer Res. 54 (20): 5401–7. PMID 7923172.
• Saccone S, Besati C, Andreozzi L; et al. (1995). "Assignment of the human cytidine deaminase (CDA) gene to chromosome 1 band p35-p36.2". Genomics. 22 (3): 661–2. doi:10.1006/geno.1994.1448. PMID 8001985.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kühn K, Bertling WM, Emmrich F (1993). "Cloning of a functional cDNA for human cytidine deaminase (CDD) and its use as a marker of monocyte/macrophage differentiation". Biochem. Biophys. Res. Commun. 190 (1): 1–7. doi:10.1006/bbrc.1993.1001. PMID 8422236.CS1 maint: Multiple names: authors list (link)
• Gran C, Bøyum A, Johansen RF; et al. (1998). "Growth inhibition of granulocyte-macrophage colony-forming cells by human cytidine deaminase requires the catalytic function of the protein". Blood. 91 (11): 4127–35. PMID 9596658.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Demontis S, Terao M, Brivio M; et al. (1999). "Isolation and characterization of the gene coding for human cytidine deaminase". Biochim. Biophys. Acta. 1443 (3): 323–33. PMID 9878810.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Somasekaram A, Jarmuz A, How A; et al. (1999). "Intracellular localization of human cytidine deaminase. Identification of a functional nuclear localization signal". J. Biol. Chem. 274 (40): 28405–12. PMID 10497201.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wistow G, Bernstein SL, Wyatt MK; et al. (2002). "Expressed sequence tag analysis of adult human lens for the NEIBank Project: over 2000 non-redundant transcripts, novel genes and splice variants". Mol. Vis. 8: 171–84. PMID 12107413.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Taysi S, Polat MF, Sari RA, Bakan E (2003). "Serum adenosine deaminase and cytidine deaminase activities in patients with systemic lupus erythematosus". Clin. Chem. Lab. Med. 40 (5): 493–5. PMID 12113294.CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bransteitter R, Pham P, Scharff MD, Goodman MF (2003). "Activation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNase". Proc. Natl. Acad. Sci. U.S.A. 100 (7): 4102–7. doi:10.1073/pnas.0730835100. PMID 12651944.CS1 maint: Multiple names: authors list (link)
• Sun ZQ, Jiang B, Zhao XS; et al. (2003). "[Expression of cytidine deaminase mRNA in bone marrow cells from patients with acute leukemia]". Zhongguo Shi Yan Xue Ye Xue Za Zhi. 11 (3): 246–50. PMID 12844405.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Vincenzetti S, Costanzi S, Cristalli G; et al. (2003). "Intersubunit interactions in human cytidine deaminase". Nucleosides Nucleotides Nucleic Acids. 22 (5–8): 1535–8. PMID 14565460.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Costanzi S, Vincenzetti S, Vita A; et al. (2003). "Human cytidine deaminase: understanding the catalytic mechanism". Nucleosides Nucleotides Nucleic Acids. 22 (5–8): 1539–43. PMID 14565461.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ge Y, Jensen TL, Stout ML; et al. (2004). "The role of cytidine deaminase and GATA1 mutations in the increased cytosine arabinoside sensitivity of Down syndrome myeloblasts and leukemia cell lines". Cancer Res. 64 (2): 728–35. PMID 14744791.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Vincenzetti S, De Sanctis G, Costanzi S; et al. (2004). "Functional properties of subunit interactions in human cytidine deaminase". Protein Eng. 16 (12): 1055–61. doi:10.1093/protein/gzg117. PMID 14983087.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chung SJ, Fromme JC, Verdine GL (2005). "Structure of human cytidine deaminase bound to a potent inhibitor". J. Med. Chem. 48 (3): 658–60. doi:10.1021/jm0496279. PMID 15689149.CS1 maint: Multiple names: authors list (link)
• Vincenzetti S, Mariani PL, Cammertoni N; et al. (2005). "Isoenzymatic forms of human cytidine deaminase". Protein Eng. Des. Sel. 17 (12): 871–7. doi:10.1093/protein/gzh101. PMID 15713780.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Costanzi S, Vincenzetti S, Cristalli G, Vita A (2007). "Human cytidine deaminase: a three-dimensional homology model of a tetrameric metallo-enzyme inferred from the crystal structure of a distantly related dimeric homologue". J. Mol. Graph. Model. 25 (1): 10–6. doi:10.1016/j.jmgm.2005.10.008. PMID 16303324.CS1 maint: Multiple names: authors list (link)