CDCa1 is a protein product of the human genome. The gene that codes for this protein is found on chromosome 1, from 150,076,963-150,079,657. The gene contains 2 exons and encodes 353 amino acids. Synonyms for CDCa1 are "hypothetical protein LOC100191040"[1] and NP_001129475. CDCa1 contains a conserved metal binding domain that is a known as Protein kinase C conserved region 2, subgroup 1. This motif is known to be a member of the C2 superfamily, which is present in phospholipases, protein kinases C, and synaptotagmins.[2] The amino acid sequence of CDCa1 can be accessed at [2] Prior to any post translational modification, CDCa1 has a molecular weight of 37.6 kdal.[3] Although scientists have not yet determined where CDCa1 functions within the cell, CDCa1 has a predicted isoelectric point of 11.636 which severely limits the places in which it can be effective. In addition, CDCa1 does not contain any predicted transmembrane domains or any predicted signal peptides.
Expression
According to the National Center for Biotechnology Information, CDCa1 has only been found to be expressed in adult individuals with some form of cancer.[4] CDCa1 is not ubiquitously expressed, and thus far scientists have only found CDCa1 expressed in the tissues of the brain, intestine, and mammary gland.
Evolutionary conservation
There are 52 known mammalian orthologs for CDCa1,[5] found in at least 10 species including Pan troglodytes, Ornithorhynchus anatinus, and Sus scrofa. There are a total of 38 completely conserved residues across these 10 species, corresponding to 10.76% conservation. Within vertebrates conservation remains high at 33 residues, corresponding to 9.3%. However, outside of vertebrates, conservation drops to a maximum of 1.98%, or 3 residues.[6]
References
