CHN2

Chimerin (chimaerin) 2
File:PBB Protein CHN2 image.jpg PDB rendering based on 1xa6.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1xa6​
Identifiers
Symbols	CHN2 ; ARHGAP3; BCH; MGC138360; RHOGAP3
External IDs	Template:OMIM5 Template:MGI HomoloGene: 31213
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO
RNA expression pattern
File:PBB GE CHN2 213385 at tn.png
File:PBB GE CHN2 207486 x at tn.png
File:PBB GE CHN2 211419 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Chimerin (chimaerin) 2, also known as CHN2, is a human gene.

This gene is a member of the chimerin family and encodes a protein with a phorbol-ester/DAG-type zinc finger, a Rho-GAP domain and an SH2 domain. This protein has GTPase-activating protein activity that is regulated by phospholipid binding and binding of diacylglycerol (DAG) induces translocation of the protein from the cytosol to the Golgi apparatus membrane. The protein plays a role in the proliferation and migration of smooth muscle cells. Decreased expression of this gene is associated with high-grade gliomas and breast tumors, and increased expression of this gene is associated with lymphomas. Mutations in this gene have been associated with schizophrenia in men. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Further reading

• Yuan S, Miller DW, Barnett GH; et al. (1995). "Identification and characterization of human beta 2-chimaerin: association with malignant transformation in astrocytoma". Cancer Res. 55 (15): 3456–61. PMID 7614486.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Leung T, How BE, Manser E, Lim L (1994). "Cerebellar beta 2-chimaerin, a GTPase-activating protein for p21 ras-related rac is specifically expressed in granule cells and has a unique N-terminal SH2 domain". J. Biol. Chem. 269 (17): 12888–92. PMID 8175705.CS1 maint: Multiple names: authors list (link)
• Caloca MJ, Fernandez N, Lewin NE; et al. (1997). "Beta2-chimaerin is a high affinity receptor for the phorbol ester tumor promoters". J. Biol. Chem. 272 (42): 26488–96. PMID 9334226.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Caloca MJ, Garcia-Bermejo ML, Blumberg PM; et al. (1999). "beta2-chimaerin is a novel target for diacylglycerol: binding properties and changes in subcellular localization mediated by ligand binding to its C1 domain". Proc. Natl. Acad. Sci. U.S.A. 96 (21): 11854–9. PMID 10518540.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Caloca MJ, Wang H, Delemos A; et al. (2001). "Phorbol esters and related analogs regulate the subcellular localization of beta 2-chimaerin, a non-protein kinase C phorbol ester receptor". J. Biol. Chem. 276 (21): 18303–12. doi:10.1074/jbc.M011368200. PMID 11278894.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wang H, Kazanietz MG (2002). "Chimaerins, novel non-protein kinase C phorbol ester receptors, associate with Tmp21-I (p23): evidence for a novel anchoring mechanism involving the chimaerin C1 domain". J. Biol. Chem. 277 (6): 4541–50. doi:10.1074/jbc.M107150200. PMID 11689559.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Scherer SW, Cheung J, MacDonald JR; et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–72. doi:10.1126/science.1083423. PMID 12690205.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nishiu M, Yanagawa R, Nakatsuka S; et al. (2003). "Microarray analysis of gene-expression profiles in diffuse large B-cell lymphoma: identification of genes related to disease progression". Jpn. J. Cancer Res. 93 (8): 894–901. PMID 12716467.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hillier LW, Fulton RS, Fulton LA; et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Caloca MJ, Wang H, Kazanietz MG (2004). "Characterization of the Rac-GAP (Rac-GTPase-activating protein) activity of beta2-chimaerin, a 'non-protein kinase C' phorbol ester receptor". Biochem. J. 375 (Pt 2): 313–21. doi:10.1042/BJ20030727. PMID 12877655.CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Canagarajah B, Leskow FC, Ho JY; et al. (2004). "Structural mechanism for lipid activation of the Rac-specific GAP, beta2-chimaerin". Cell. 119 (3): 407–18. doi:10.1016/j.cell.2004.10.012. PMID 15507211.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hashimoto R, Yoshida M, Kunugi H; et al. (2005). "A missense polymorphism (H204R) of a Rho GTPase-activating protein, the chimerin 2 gene, is associated with schizophrenia in men". Schizophrenia Research. 73 (2–3): 383–5. doi:10.1016/j.schres.2004.01.017. PMID 15653288.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Barrios-Rodiles M, Brown KR, Ozdamar B; et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. doi:10.1126/science.1105776. PMID 15761153.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yang C, Liu Y, Leskow FC; et al. (2005). "Rac-GAP-dependent inhibition of breast cancer cell proliferation by {beta}2-chimerin". J. Biol. Chem. 280 (26): 24363–70. doi:10.1074/jbc.M411629200. PMID 15863513.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kimura K, Wakamatsu A, Suzuki Y; et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Siliceo M, García-Bernal D, Carrasco S; et al. (2006). "Beta2-chimaerin provides a diacylglycerol-dependent mechanism for regulation of adhesion and chemotaxis of T cells". J. Cell. Sci. 119 (Pt 1): 141–52. doi:10.1242/jcs.02722. PMID 16352660.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yang C, Liu Y, Lemmon MA, Kazanietz MG (2006). "Essential role for Rac in heregulin beta1 mitogenic signaling: a mechanism that involves epidermal growth factor receptor and is independent of ErbB4". Mol. Cell. Biol. 26 (3): 831–42. doi:10.1128/MCB.26.3.831-842.2006. PMID 16428439.CS1 maint: Multiple names: authors list (link)