CHP (gene)

Calcium binding protein P22
File:PBB Protein CHP image.jpg PDB rendering based on 2ct9.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 2ct9​, 2e30​
Identifiers
Symbols	CHP ; SLC9A1BP
External IDs	Template:OMIM5 Template:MGI HomoloGene: 5235
Gene ontology Molecular function Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE CHP 214665 s at tn.png
File:PBB GE CHP 207993 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Calcium binding protein P22, also known as CHP, is a human gene.

The protein encoded by this gene is a phosphoprotein that binds to the sodium-potassium exchangers (NHEs). This protein serves as an essential cofactor which supports the physiological activity of NHE family members. It has protein sequence similarity to calcineurin B and it is also known to be an endogenous inhibitor of calcineurin activity.

Further reading

• Robertson NG, Khetarpal U, Gutiérrez-Espeleta GA; et al. (1995). "Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening". Genomics. 23 (1): 42–50. doi:10.1006/geno.1994.1457. PMID 7829101.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Barroso MR, Bernd KK, DeWitt ND; et al. (1996). "A novel Ca2+-binding protein, p22, is required for constitutive membrane traffic". J. Biol. Chem. 271 (17): 10183–7. PMID 8626580.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lin X, Barber DL (1996). "A calcineurin homologous protein inhibits GTPase-stimulated Na-H exchange". Proc. Natl. Acad. Sci. U.S.A. 93 (22): 12631–6. PMID 8901634.
• Lin X, Sikkink RA, Rusnak F, Barber DL (2000). "Inhibition of calcineurin phosphatase activity by a calcineurin B homologous protein". J. Biol. Chem. 274 (51): 36125–31. PMID 10593895.CS1 maint: Multiple names: authors list (link)
• Pang T, Su X, Wakabayashi S, Shigekawa M (2001). "Calcineurin homologous protein as an essential cofactor for Na+/H+ exchangers". J. Biol. Chem. 276 (20): 17367–72. doi:10.1074/jbc.M100296200. PMID 11350981.CS1 maint: Multiple names: authors list (link)
• Matsumoto M, Miyake Y, Nagita M; et al. (2001). "A serine/threonine kinase which causes apoptosis-like cell death interacts with a calcineurin B-like protein capable of binding Na(+)/H(+) exchanger". J. Biochem. 130 (2): 217–25. PMID 11481038.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nakamura N, Miyake Y, Matsushita M; et al. (2003). "KIF1Bbeta2, capable of interacting with CHP, is localized to synaptic vesicles". J. Biochem. 132 (3): 483–91. PMID 12204119.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Pang T, Wakabayashi S, Shigekawa M (2003). "Expression of calcineurin B homologous protein 2 protects serum deprivation-induced cell death by serum-independent activation of Na+/H+ exchanger". J. Biol. Chem. 277 (46): 43771–7. doi:10.1074/jbc.M208313200. PMID 12226101.CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Inoue H, Nakamura Y, Nagita M; et al. (2003). "Calcineurin homologous protein isoform 2 (CHP2), Na+/H+ exchangers-binding protein, is expressed in intestinal epithelium". Biol. Pharm. Bull. 26 (2): 148–55. PMID 12576672.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Pang T, Hisamitsu T, Mori H; et al. (2004). "Role of calcineurin B homologous protein in pH regulation by the Na+/H+ exchanger 1: tightly bound Ca2+ ions as important structural elements". Biochemistry. 43 (12): 3628–36. doi:10.1021/bi0360004. PMID 15035633.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Andrade J, Pearce ST, Zhao H, Barroso M (2005). "Interactions among p22, glyceraldehyde-3-phosphate dehydrogenase and microtubules". Biochem. J. 384 (Pt 2): 327–36. doi:10.1042/BJ20040622. PMID 15312048.CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ben Ammar Y, Takeda S, Sugawara M; et al. (2006). "Crystallization and preliminary crystallographic analysis of the human calcineurin homologous protein CHP2 bound to the cytoplasmic region of the Na+/H+ exchanger NHE1". Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 61 (Pt 10): 956–8. doi:10.1107/S1744309105030836. PMID 16511206.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mishima M, Wakabayashi S, Kojima C (2007). "Solution structure of the cytoplasmic region of Na+/H+ exchanger 1 complexed with essential cofactor calcineurin B homologous protein 1". J. Biol. Chem. 282 (4): 2741–51. doi:10.1074/jbc.M604092200. PMID 17050540.CS1 maint: Multiple names: authors list (link)