CMTM3

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Identifiers
Aliases
External IDs	GeneCards: [1]
Orthologs
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a
Wikidata
View/Edit Human

CKLF like MARVEL transmembrane domain containing 3 is a protein that in humans is encoded by the CMTM3 gene.

Function

This gene belongs to the chemokine-like factor gene superfamily, a novel family that is similar to the chemokine and the transmembrane 4 superfamilies of signaling molecules. This gene is one of several chemokine-like factor genes located in a cluster on chromosome 16. Alternatively spliced transcript variants containing different 5' UTRs, but encoding the same protein, have been identified. [provided by RefSeq, Jul 2008].

Further reading

• Han W, Ding P, Xu M, Wang L, Rui M, Shi S, Liu Y, Zheng Y, Chen Y, Yang T, Ma D (2003). "Identification of eight genes encoding chemokine-like factor superfamily members 1-8 (CKLFSF1-8) by in silico cloning and experimental validation". Genomics. 81 (6): 609–17. PMID 12782130.
• Zhong J, Wang Y, Qiu X, Mo X, Liu Y, Li T, Song Q, Ma D, Han W (2006). "Characterization and expression profile of CMTM3/CKLFSF3". J. Biochem. Mol. Biol. 39 (5): 537–45. PMID 17002874.
• Wang Y, Li T, Qiu X, Mo X, Zhang Y, Song Q, Ma D, Han W (2008). "CMTM3 can affect the transcription activity of androgen receptor and inhibit the expression level of PSA in LNCaP cells". Biochem. Biophys. Res. Commun. 371 (1): 54–8. doi:10.1016/j.bbrc.2008.03.143. PMID 18402773.
• Xie J, Yuan Y, Liu Z, Xiao Y, Zhang X, Qin C, Sheng Z, Xu T, Wang X (2014). "CMTM3 is frequently reduced in clear cell renal cell carcinoma and exhibits tumor suppressor activities". Clin Transl Oncol. 16 (4): 402–9. doi:10.1007/s12094-013-1092-3. PMID 23907292.
• Su Y, Lin Y, Zhang L, Liu B, Yuan W, Mo X, Wang X, Li H, Xing X, Cheng X, Dong B, Hu Y, Du H, Zhu Y, Ding N, Li J, Liu W, Ma Y, Qiu X, Ji J, Han W (2014). "CMTM3 inhibits cell migration and invasion and correlates with favorable prognosis in gastric cancer". Cancer Sci. 105 (1): 26–34. doi:10.1111/cas.12304. PMC 4317871. PMID 24131472.
• Delic S, Thuy A, Schulze M, Proescholdt MA, Dietrich P, Bosserhoff AK, Riemenschneider MJ (2015). "Systematic investigation of CMTM family genes suggests relevance to glioblastoma pathogenesis and CMTM1 and CMTM3 as priority targets". Genes Chromosomes Cancer. 54 (7): 433–43. doi:10.1002/gcc.22255. PMID 25931111.
• Zhang H, Zhang J, Nan X, Li X, Qu J, Hong Y, Sun L, Chen Y, Li T (2015). "CMTM3 inhibits cell growth and migration and predicts favorable survival in oral squamous cell carcinoma". Tumour Biol. 36 (10): 7849–58. doi:10.1007/s13277-015-3504-1. PMID 25946973.
• Hu F, Yuan W, Wang X, Sheng Z, Yuan Y, Qin C, He C, Xu T (2015). "CMTM3 is reduced in prostate cancer and inhibits migration, invasion and growth of LNCaP cells". Clin Transl Oncol. 17 (8): 632–9. doi:10.1007/s12094-015-1288-9. PMID 25990505.
• Yuan W, Li T, Mo X, Wang X, Liu B, Wang W, Su Y, Xu L, Han W (2016). "Knockdown of CMTM3 promotes metastasis of gastric cancer via the STAT3/Twist1/EMT signaling pathway". Oncotarget. 7 (20): 29507–19. doi:10.18632/oncotarget.8789. PMC 5045413. PMID 27121055.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.