CNTN1

Contactin 1
Identifiers
Symbols	CNTN1 ; F3; GP135
External IDs	Template:OMIM5 Template:MGI HomoloGene: 7274
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Contactin 1, also known as CNTN1, is a human gene.

The protein encoded by this gene is a member of the immunoglobulin superfamily. It is a glycosylphosphatidylinositol (GPI)-anchored neuronal membrane protein that functions as a cell adhesion molecule. It may play a role in the formation of axon connections in the developing nervous system. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Further reading

• Walsh FS, Doherty P (1992). "Glycosylphosphatidylinositol anchored recognition molecules that function in axonal fasciculation, growth and guidance in the nervous system". Cell Biol. Int. Rep. 15 (11): 1151–66. PMID 1838307.
• Peles E, Schlessinger J, Grumet M (1998). "Multi-ligand interactions with receptor-like protein tyrosine phosphatase beta: implications for intercellular signaling". Trends Biochem. Sci. 23 (4): 121–4. PMID 9584610.CS1 maint: Multiple names: authors list (link)
• Olive S, Dubois C, Schachner M, Rougon G (1995). "The F3 neuronal glycosylphosphatidylinositol-linked molecule is localized to glycolipid-enriched membrane subdomains and interacts with L1 and fyn kinase in cerebellum". J. Neurochem. 65 (5): 2307–17. PMID 7595520.CS1 maint: Multiple names: authors list (link)
• Peles E, Nativ M, Campbell PL; et al. (1995). "The carbonic anhydrase domain of receptor tyrosine phosphatase beta is a functional ligand for the axonal cell recognition molecule contactin". Cell. 82 (2): 251–60. PMID 7628014.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Berglund EO, Ranscht B (1994). "Molecular cloning and in situ localization of the human contactin gene (CNTN1) on chromosome 12q11-q12". Genomics. 21 (3): 571–82. doi:10.1006/geno.1994.1316. PMID 7959734.
• Reid RA, Bronson DD, Young KM, Hemperly JJ (1994). "Identification and characterization of the human cell adhesion molecule contactin". Brain Res. Mol. Brain Res. 21 (1–2): 1–8. PMID 8164510.CS1 maint: Multiple names: authors list (link)
• Yoshihara Y, Kawasaki M, Tamada A; et al. (1996). "Overlapping and differential expression of BIG-2, BIG-1, TAG-1, and F3: four members of an axon-associated cell adhesion molecule subgroup of the immunoglobulin superfamily". J. Neurobiol. 28 (1): 51–69. doi:10.1002/neu.480280106. PMID 8586965.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sakurai T, Lustig M, Nativ M; et al. (1997). "Induction of neurite outgrowth through contactin and Nr-CAM by extracellular regions of glial receptor tyrosine phosphatase beta". J. Cell Biol. 136 (4): 907–18. PMID 9049255.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Xiao ZC, Taylor J, Montag D; et al. (1997). "Distinct effects of recombinant tenascin-R domains in neuronal cell functions and identification of the domain interacting with the neuronal recognition molecule F3/11". Eur. J. Neurosci. 8 (4): 766–82. PMID 9081628.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Xiao ZC, Hillenbrand R, Schachner M; et al. (1997). "Signaling events following the interaction of the neuronal adhesion molecule F3 with the N-terminal domain of tenascin-R". J. Neurosci. Res. 49 (6): 698–709. PMID 9335257.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Pierre K, Rougon G, Allard M; et al. (1998). "Regulated expression of the cell adhesion glycoprotein F3 in adult hypothalamic magnocellular neurons". J. Neurosci. 18 (14): 5333–43. PMID 9651216.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Revest JM, Faivre-Sarrailh C, Maeda N; et al. (1999). "The interaction between F3 immunoglobulin domains and protein tyrosine phosphatases zeta/beta triggers bidirectional signalling between neurons and glial cells". Eur. J. Neurosci. 11 (4): 1134–47. PMID 10103110.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Berglund EO, Murai KK, Fredette B; et al. (2000). "Ataxia and abnormal cerebellar microorganization in mice with ablated contactin gene expression". Neuron. 24 (3): 739–50. PMID 10595523.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Pierre K, Dupouy B, Allard M; et al. (2001). "Mobilization of the cell adhesion glycoprotein F3/contactin to axonal surfaces is activity dependent". Eur. J. Neurosci. 14 (4): 645–56. PMID 11556889.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kazarinova-Noyes K, Malhotra JD, McEwen DP; et al. (2001). "Contactin associates with Na+ channels and increases their functional expression". J. Neurosci. 21 (19): 7517–25. PMID 11567041.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Pavlou O, Theodorakis K, Falk J; et al. (2002). "Analysis of interactions of the adhesion molecule TAG-1 and its domains with other immunoglobulin superfamily members". Mol. Cell. Neurosci. 20 (3): 367–81. PMID 12139915.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Garwood J, Heck N, Reichardt F, Faissner A (2003). "Phosphacan short isoform, a novel non-proteoglycan variant of phosphacan/receptor protein tyrosine phosphatase-beta, interacts with neuronal receptors and promotes neurite outgrowth". J. Biol. Chem. 278 (26): 24164–73. doi:10.1074/jbc.M211721200. PMID 12700241.CS1 maint: Multiple names: authors list (link)