CODOX-M/IVAC regimen

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Aparna Vuppala, M.B.B.S. [2]

Synonyms and keywords:CODOX-M/IVAC Regimen; Cyclophosphamide-Oncovin-Doxorubicin-Methotrexate/Ifosfamide, VePesid, AraC Regimen; McGrath Regimen

Overview

CODOX-M/IVAC regimen refers to a regimen consisting of cyclophosphamide, vincristine, doxorubicin and high-dose methotrexate (CODOX-M) alternating with ifosfamide, etoposide and high-dose cytarabine (IVAC), used as a treatment for aggressive forms of non-Hodgkin's lymphoma; also used as primary treatment for AIDS-related and high-risk Burkitt's lymphoma. Intrathecal cytarabine and methotrexate are included in this regimen as either prophylaxis or treatment for central nervous system (CNS) involvement.

Regimen

CCyclophosphamide

VVincristine

DOXDoxorubicin

MMethotrexate

IIfosfamide

VVepesid (etoposide)

ACAra-C (cytarabine)

Indications

• AIDS-related and high-risk Burkitt's lymphoma