COL15A1

Collagen, type XV, alpha 1
Identifiers
Symbols	COL15A1 ; FLJ38566
External IDs	Template:OMIM5 Template:MGI HomoloGene: 1396
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Collagen, type XV, alpha 1, also known as COL15A1, is a human gene.

This gene encodes the alpha chain of type XV collagen, a member of the FACIT collagen family (fibril-associated collagens with interrupted helices). Type XV collagen has a wide tissue distribution but the strongest expression is localized to basement membrane zones so it may function to adhere basement membranes to underlying connective tissue stroma. Mouse studies have shown that collagen XV deficiency is associated with muscle and microvessel deterioration.

Further reading

• Myers JC, Kivirikko S, Gordon MK; et al. (1992). "Identification of a previously unknown human collagen chain, alpha 1(XV), characterized by extensive interruptions in the triple-helical region". Proc. Natl. Acad. Sci. U.S.A. 89 (21): 10144–8. PMID 1279671.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Huebner K, Cannizzaro LA, Jabs EW; et al. (1992). "Chromosomal assignment of a gene encoding a new collagen type (COL15A1) to 9q21 --> q22". Genomics. 14 (2): 220–4. PMID 1427836.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kivirikko S, Heinämäki P, Rehn M; et al. (1994). "Primary structure of the alpha 1 chain of human type XV collagen and exon-intron organization in the 3' region of the corresponding gene". J. Biol. Chem. 269 (7): 4773–9. PMID 8106446.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Muragaki Y, Abe N, Ninomiya Y; et al. (1994). "The human alpha 1(XV) collagen chain contains a large amino-terminal non-triple helical domain with a tandem repeat structure and homology to alpha 1(XVIII) collagen". J. Biol. Chem. 269 (6): 4042–6. PMID 8307960.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Myers JC, Dion AS, Abraham V, Amenta PS (1997). "Type XV collagen exhibits a widespread distribution in human tissues but a distinct localization in basement membrane zones". Cell Tissue Res. 286 (3): 493–505. PMID 8929352.CS1 maint: Multiple names: authors list (link)
• Hägg PM, Hägg PO, Peltonen S; et al. (1997). "Location of type XV collagen in human tissues and its accumulation in the interstitial matrix of the fibrotic kidney". Am. J. Pathol. 150 (6): 2075–86. PMID 9176399.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hägg PM, Muona A, Liétard J; et al. (1998). "Complete exon-intron organization of the human gene for the alpha1 chain of type XV collagen (COL15A1) and comparison with the homologous COL18A1 gene". J. Biol. Chem. 273 (28): 17824–31. PMID 9651385.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ramchandran R, Dhanabal M, Volk R; et al. (1999). "Antiangiogenic activity of restin, NC10 domain of human collagen XV: comparison to endostatin". Biochem. Biophys. Res. Commun. 255 (3): 735–9. doi:10.1006/bbrc.1999.0248. PMID 10049780.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Li D, Clark CC, Myers JC (2000). "Basement membrane zone type XV collagen is a disulfide-bonded chondroitin sulfate proteoglycan in human tissues and cultured cells". J. Biol. Chem. 275 (29): 22339–47. doi:10.1074/jbc.M000519200. PMID 10791950.CS1 maint: Multiple names: authors list (link)
• Nishi M, Mizushima A, Nakagawara K, Takeshima H (2000). "Characterization of human junctophilin subtype genes". Biochem. Biophys. Res. Commun. 273 (3): 920–7. doi:10.1006/bbrc.2000.3011. PMID 10891348.CS1 maint: Multiple names: authors list (link)
• Eklund L, Muona A, Liétard J, Pihlajaniemi T (2001). "Structure of the mouse type XV collagen gene, Col15a1, comparison with the human COL15A1 gene and functional analysis of the promoters of both genes". Matrix Biol. 19 (6): 489–500. PMID 11068203.CS1 maint: Multiple names: authors list (link)
• Tomono Y, Naito I, Ando K; et al. (2002). "Epitope-defined monoclonal antibodies against multiplexin collagens demonstrate that type XV and XVIII collagens are expressed in specialized basement membranes". Cell Struct. Funct. 27 (1): 9–20. PMID 11937714.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Humphray SJ, Oliver K, Hunt AR; et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. doi:10.1038/nature02465. PMID 15164053.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Myers JC, Amenta PS, Dion AS; et al. (2007). "The molecular structure of human tissue type XV presents a unique conformation among the collagens". Biochem. J. 404 (3): 535–44. doi:10.1042/BJ20070201. PMID 17355226.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)