CORONA Trial
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Click here to download slides for CORONA Trial.
Objective
To study the effects of rosuvastatin 10 mg daily in patients with congestive heart failure.
Methods
Controlled Rosuvastatin Multinational Trial in Heart Failure (CORONA) was a double-blinded, randomized, placebo controlled trial wherein 5011 patients with congestive heart failure NYHA Class II, III or IV ischemic, systolic heart failure were enrolled and randomly assigned to treatment with either 10 mg rosuvastatin daily or placebo. The primary outcome was death from cardiovascular causes, non-fatal MI or non-fatal stroke.
Results
Compared to placebo, rosuvastatin reduced serum LDL levels and raised HDL and triglyceride levels. However, there was no significant reduction in mortality rates from cardiovascular causes, coronary events and all-cause mortality.[1][2][3][4]
References
- ↑ Kjekshus J, Apetrei E, Barrios V; et al. (2007). "Rosuvastatin in older patients with systolic heart failure". The New England Journal of Medicine. 357 (22): 2248–61. doi:10.1056/NEJMoa0706201. PMID 17984166. Unknown parameter
|month=ignored (help) - ↑ van der Harst P, Slart RH, Tio RA; et al. (2010). "Effects of rosuvastatin on coronary flow reserve and metabolic mismatch in patients with heart failure (from the CORONA Study)". The American Journal of Cardiology. 105 (4): 517–21. doi:10.1016/j.amjcard.2009.10.021. PMID 20152247. Unknown parameter
|month=ignored (help) - ↑ Lorgelly PK, Briggs AH, Wedel H; et al. (2010). "An economic evaluation of rosuvastatin treatment in systolic heart failure: evidence from the CORONA trial". European Journal of Heart Failure. 12 (1): 66–74. doi:10.1093/eurjhf/hfp172. PMC 2796144. PMID 20023047. Unknown parameter
|month=ignored (help) - ↑ McMurray JJ, Kjekshus J, Gullestad L; et al. (2009). "Effects of statin therapy according to plasma high-sensitivity C-reactive protein concentration in the Controlled Rosuvastatin Multinational Trial in Heart Failure (CORONA): a retrospective analysis". Circulation. 120 (22): 2188–96. doi:10.1161/CIRCULATIONAHA.109.849117. PMID 19917888. Unknown parameter
|month=ignored (help)