COX7A1

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Identifiers
Aliases
External IDs	GeneCards: [1]
Orthologs
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a
Wikidata
View/Edit Human

Cytochrome c oxidase polypeptide 7A1, mitochondrial is an enzyme that in humans is encoded by the COX7A1 gene.

Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes polypeptide 1 (muscle isoform) of subunit VIIa and the polypeptide 1 is present only in muscle tissues. Other polypeptides of subunit VIIa are present in both muscle and nonmuscle tissues, and are encoded by different genes.

External links

• Human COX7A1 genome location and COX7A1 gene details page in the UCSC Genome Browser.

Further reading

• Lenka N, Vijayasarathy C, Mullick J, Avadhani NG (1998). "Structural organization and transcription regulation of nuclear genes encoding the mammalian cytochrome c oxidase complex". Prog. Nucleic Acid Res. Mol. Biol. Progress in Nucleic Acid Research and Molecular Biology. 61: 309–344. doi:10.1016/S0079-6603(08)60830-2. ISBN 978-0-12-540061-9. PMID 9752724.
• Van Kuilenburg AB, Van Beeumen JJ, Van der Meer NM, Muijsers AO (1992). "Subunits VIIa,b,c of human cytochrome c oxidase. Identification of both 'heart-type' and 'liver-type' isoforms of subunit VIIa in human heart". Eur. J. Biochem. 203 (1–2): 193–199. doi:10.1111/j.1432-1033.1992.tb19847.x. PMID 1309697.
• Wolz W, Kress W, Mueller CR (1998). "Genomic sequence and organization of the human gene for cytochrome c oxidase subunit (COX7A1) VIIa-M". Genomics. 45 (2): 438–442. doi:10.1006/geno.1997.4937. PMID 9344674.
• Schmidt TR, Goodman M, Grossman LI (1999). "Molecular evolution of the COX7A gene family in primates". Mol. Biol. Evol. 16 (5): 619–26. doi:10.1093/oxfordjournals.molbev.a026144. PMID 10335655.
• Yu M, Jaradat SA, Grossman LI (2002). "Genomic organization and promoter regulation of human cytochrome c oxidase subunit VII heart/muscle isoform (COX7AH)". Biochim. Biophys. Acta. 1574 (3): 345–53. doi:10.1016/s0167-4781(02)00228-2. PMID 11997101.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19". Nature. 428 (6982): 529–535. doi:10.1038/nature02399. PMID 15057824.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.