CTSL2

Cathepsin L2
PDB rendering based on 1fh0.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1fh0​
Identifiers
Symbols	CTSL2 ; CATL2; CTSU; CTSV; MGC125957
External IDs	Template:OMIM5 Template:MGI HomoloGene: 74298
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Cathepsin L2, also known as CTSL2, is a human gene.

The protein encoded by this gene, a member of the peptidase C1 family, is a lysosomal cysteine proteinase that may play an important role in corneal physiology. This gene is expressed in colorectal and breast carcinomas but not in normal colon, mammary gland, or peritumoral tissues, suggesting a possible role for this gene in tumor processes.

Further reading

• Santamaría I, Velasco G, Cazorla M; et al. (1998). "Cathepsin L2, a novel human cysteine proteinase produced by breast and colorectal carcinomas". Cancer Res. 58 (8): 1624–30. PMID 9563472.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Adachi W, Kawamoto S, Ohno I; et al. (1998). "Isolation and characterization of human cathepsin V: a major proteinase in corneal epithelium". Invest. Ophthalmol. Vis. Sci. 39 (10): 1789–96. PMID 9727401.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Brömme D, Li Z, Barnes M, Mehler E (1999). "Human cathepsin V functional expression, tissue distribution, electrostatic surface potential, enzymatic characterization, and chromosomal localization". Biochemistry. 38 (8): 2377–85. doi:10.1021/bi982175f. PMID 10029531.CS1 maint: Multiple names: authors list (link)
• Itoh R, Kawamoto S, Adachi W; et al. (1999). "Genomic organization and chromosomal localization of the human cathepsin L2 gene". DNA Res. 6 (2): 137–40. PMID 10382972.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Somoza JR, Zhan H, Bowman KK; et al. (2000). "Crystal structure of human cathepsin V.". Biochemistry. 39 (41): 12543–51. PMID 11027133.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bernard D, Méhul B, Thomas-Collignon A; et al. (2003). "Analysis of proteins with caseinolytic activity in a human stratum corneum extract revealed a yet unidentified cysteine protease and identified the so-called "stratum corneum thiol protease" as cathepsin l2". J. Invest. Dermatol. 120 (4): 592–600. doi:10.1046/j.1523-1747.2003.12086.x. PMID 12648222.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tolosa E, Li W, Yasuda Y; et al. (2003). "Cathepsin V is involved in the degradation of invariant chain in human thymus and is overexpressed in myasthenia gravis". J. Clin. Invest. 112 (4): 517–26. doi:10.1172/JCI200318028. PMID 12925692.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Clark HF, Gurney AL, Abaya E; et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMID 12975309.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Humphray SJ, Oliver K, Hunt AR; et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. doi:10.1038/nature02465. PMID 15164053.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yasuda Y, Li Z, Greenbaum D; et al. (2004). "Cathepsin V, a novel and potent elastolytic activity expressed in activated macrophages". J. Biol. Chem. 279 (35): 36761–70. doi:10.1074/jbc.M403986200. PMID 15192101.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hagemann S, Günther T, Dennemärker J; et al. (2005). "The human cysteine protease cathepsin V can compensate for murine cathepsin L in mouse epidermis and hair follicles". Eur. J. Cell Biol. 83 (11–12): 775–80. PMID 15679121.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Cheng T, Hitomi K, van Vlijmen-Willems IM; et al. (2006). "Cystatin M/E is a high affinity inhibitor of cathepsin V and cathepsin L by a reactive site that is distinct from the legumain-binding site. A novel clue for the role of cystatin M/E in epidermal cornification". J. Biol. Chem. 281 (23): 15893–9. doi:10.1074/jbc.M600694200. PMID 16565075.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Burden RE, Snoddy P, Jefferies CA; et al. (2007). "Inhibition of cathepsin L-like proteases by cathepsin V propeptide". Biol. Chem. 388 (5): 541–5. doi:10.1515/BC.2007.053. PMID 17516850.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Viken MK, Sollid HD, Joner G; et al. (2007). "Polymorphisms in the cathepsin L2 (CTSL2) gene show association with type 1 diabetes and early-onset myasthenia gravis". Hum. Immunol. 68 (9): 748–55. doi:10.1016/j.humimm.2007.05.009. PMID 17869649.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)