CTSZ

Cathepsin Z
PDB rendering based on 1deu.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1deu​, 1ef7​
Identifiers
Symbols	CTSZ ; CTSX
External IDs	Template:OMIM5 Template:MGI HomoloGene: 1022
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Cathepsin Z, also known as CTSZ, is a human gene.

The protein encoded by this gene is a lysosomal cysteine proteinase and member of the peptidase C1 family. It exhibits both carboxy-monopeptidase and carboxy-dipeptidase activities. The encoded protein has also been known as cathepsin X and cathepsin P. This gene is expressed ubiquitously in cancer cell lines and primary tumors and, like other members of this family, may be involved in tumorigenesis. At least two transcript variants of this gene have been found, but the full-length nature of only one of them has been determined.

Further reading

• Santamaría I, Velasco G, Pendás AM; et al. (1998). "Cathepsin Z, a novel human cysteine proteinase with a short propeptide domain and a unique chromosomal location". J. Biol. Chem. 273 (27): 16816–23. PMID 9642240.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nägler DK, Ménard R (1998). "Human cathepsin X: a novel cysteine protease of the papain family with a very short proregion and unique insertions". FEBS Lett. 434 (1–2): 135–9. PMID 9738465.
• Pungercar J, Ivanovski G (2000). "Identification and molecular cloning of cathepsin P, a novel human putative cysteine protease of the papain family". Pflugers Arch. 439 (3 Suppl): R116–8. PMID 10653162.
• Pungercar J, Viyjak A, Ivanovski G, Krizaj I (2000). "Tissue expression and immunolocalization of a novel human cathepsin P.". Pflugers Arch. 439 (3 Suppl): R119–21. PMID 10653163.CS1 maint: Multiple names: authors list (link)
• Sivaraman J, Nägler DK, Zhang R; et al. (2000). "Crystal structure of human procathepsin X: a cysteine protease with the proregion covalently linked to the active site cysteine". J. Mol. Biol. 295 (4): 939–51. doi:10.1006/jmbi.1999.3410. PMID 10656802.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Guncar G, Klemencic I, Turk B; et al. (2000). "Crystal structure of cathepsin X: a flip-flop of the ring of His23 allows carboxy-monopeptidase and carboxy-dipeptidase activity of the protease". Structure. 8 (3): 305–13. PMID 10745011.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Deussing J, von Olshausen I, Peters C (2000). "Murine and human cathepsin Z: cDNA-cloning, characterization of the genes and chromosomal localization". Biochim. Biophys. Acta. 1491 (1–3): 93–106. PMID 10760573.CS1 maint: Multiple names: authors list (link)
• Bonthron DT, Hayward BE, Moran V, Strain L (2000). "Characterization of TH1 and CTSZ, two non-imprinted genes downstream of GNAS1 in chromosome 20q13". Hum. Genet. 107 (2): 165–75. PMID 11030415.CS1 maint: Multiple names: authors list (link)
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. PMID 11076863.CS1 maint: Multiple names: authors list (link)
• Simpson JC, Wellenreuther R, Poustka A; et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMID 11256614.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Deloukas P, Matthews LH, Ashurst J; et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wiemann S, Arlt D, Huber W; et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMID 15489336.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Puzer L, Barros NM, Oliveira V; et al. (2005). "Defining the substrate specificity of mouse cathepsin P.". Arch. Biochem. Biophys. 435 (1): 190–6. doi:10.1016/j.abb.2004.12.007. PMID 15680921.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mehrle A, Rosenfelder H, Schupp I; et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMID 16381901.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lechner AM, Assfalg-Machleidt I, Zahler S; et al. (2007). "RGD-dependent binding of procathepsin X to integrin alphavbeta3 mediates cell-adhesive properties". J. Biol. Chem. 281 (51): 39588–97. doi:10.1074/jbc.M513439200. PMID 17065156.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)