Cortactin-binding protein 2 is a protein that in humans is encoded by the CTTNBP2 gene .[1] [2]
Function This gene encodes a protein with six ankyrin repeats and several proline-rich regions. A similar gene in rat interacts with a central regulator of the actin cytoskeleton.[2]
Interactions CTTNBP2 has been shown to interact with:
Model organisms Model organisms have been used in the study of CTTNBP2 function. A conditional knockout mouse line called Cttnbp2tm1b(KOMP)Wtsi was generated at the Wellcome Trust Sanger Institute .[4] phenotypic screen [5] [6] [7] [8] [9] [10]
Cttnbp2 knockout mouse phenotype
Characteristic
Phenotype
All data available at.[5] [10]
Peripheral blood leukocytes 6 Weeks
Normal
Haematology Normal
Homozygous viability at P14
Normal
Homozygous Fertility
Normal
Body weight
Normal
Neurological assessment
Normal
Grip strength
Normal
Dysmorphology Normal
Indirect calorimetry Normal
Glucose tolerance test Normal
Auditory brainstem response Normal
DEXA Abnormal
Radiography Normal
Eye morphology
Normal
Clinical chemistry Normal
Haematology Normal
Peripheral blood leukocytes 16 Weeks
Normal
Heart weight
Normal
Salmonella Normal
Cytotoxic T Cell Function
Normal
Spleen Immunophenotyping
Normal
Mesenteric Lymph Node Immunophenotyping
Normal
Bone Marrow Immunophenotyping
Normal
Epidermal Immune Composition
Normal
Trichuris Challenge
Normal
References
↑ Cheung J, Petek E, Nakabayashi K, Tsui LC, Vincent JB, Scherer SW (Nov 2001). "Identification of the human cortactin-binding protein-2 gene from the autism candidate region at 7q31". Genomics . 78 (1–2): 7–11. doi :10.1006/geno.2001.6651 . PMID 11707066 . ↑ 2.0 2.1 "Entrez Gene: CTTNBP2 cortactin binding protein 2" .↑ 3.0 3.1 3.2 3.3 3.4 Goudreault M, D'Ambrosio LM, Kean MJ, Mullin MJ, Larsen BG, Sanchez A, Chaudhry S, Chen GI, Sicheri F, Nesvizhskii AI, Aebersold R, Raught B, Gingras AC (Jan 2009). "A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein" . Mol. Cell. Proteomics . 8 (1): 157–71. doi :10.1074/mcp.M800266-MCP200 . PMC 2621004 PMID 18782753 . ↑ Gerdin AK (2010). "The Sanger Mouse Genetics Programme: high throughput characterisation of knockout mice" . Acta Ophthalmologica . 88 . doi :10.1111/j.1755-3768.2010.4142.x . ↑ 5.0 5.1 "International Mouse Phenotyping Consortium" .↑ Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A (Jun 2011). "A conditional knockout resource for the genome-wide study of mouse gene function" . Nature . 474 (7351): 337–42. doi :10.1038/nature10163 . PMC 3572410 PMID 21677750 . ↑ Dolgin E (Jun 2011). "Mouse library set to be knockout". Nature . 474 (7351): 262–3. doi :10.1038/474262a . PMID 21677718 . ↑ Collins FS, Rossant J, Wurst W (Jan 2007). "A mouse for all reasons". Cell . 128 (1): 9–13. doi :10.1016/j.cell.2006.12.018 . PMID 17218247 . ↑ White JK, Gerdin AK, Karp NA, Ryder E, Buljan M, Bussell JN, Salisbury J, Clare S, Ingham NJ, Podrini C, Houghton R, Estabel J, Bottomley JR, Melvin DG, Sunter D, Adams NC, Sanger Institute Mouse Genetics Project, Tannahill D, Logan DW, Macarthur DG, Flint J, Mahajan VB, Tsang SH, Smyth I, Watt FM, Skarnes WC, Dougan G, Adams DJ, Ramirez-Solis R, Bradley A, Steel KP (2013). "Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes" . Cell . 154 (2): 452–64. doi :10.1016/j.cell.2013.06.022 . PMC 3717207 PMID 23870131 . ↑ 10.0 10.1 "Infection and Immunity Immunophenotyping (3i) Consortium" .
External links Further reading
Ohoka Y, Takai Y (1998). "Isolation and characterization of cortactin isoforms and a novel cortactin-binding protein, CBP90". Genes Cells . 3 (9): 603–12. doi :10.1046/j.1365-2443.1998.00216.x . PMID 9813110 . Nagase T, Kikuno R, Hattori A, Kondo Y, Okumura K, Ohara O (2000). "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res . 7 (6): 347–55. doi :10.1093/dnares/7.6.347 . PMID 11214970 . Zink D, Amaral MD, Englmann A, Lang S, Clarke LA, Rudolph C, Alt F, Luther K, Braz C, Sadoni N, Rosenecker J, Schindelhauer D (2004). "Transcription-dependent spatial arrangements of CFTR and adjacent genes in human cell nuclei" . J. Cell Biol . 166 (6): 815–25. doi :10.1083/jcb.200404107 . PMC 2172106 PMID 15364959 .
