Caspase 3

Caspase 3, apoptosis-related cysteine peptidase
PDB rendering based on 1rhk.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1cp3​, 1gfw​, 1i3o​, 1nme​, 1nmq​, 1nms​, 1pau​, 1qx3​, 1re1​, 1rhj​, 1rhk​, 1rhm​, 1rhq​, 1rhr​, 1rhu​, 2c1e​, 2c2k​, 2c2m​, 2c2o​, 2cdr​, 2cjx​, 2cjy​, 2cnk​, 2cnl​, 2cnn​, 2cno​, 2dko​, 2h5i​, 2h5j​, 2h65​, 2j30​, 2j31​, 2j32​, 2j33​
Identifiers
Symbols	CASP3 ; CPP32; CPP32B; SCA-1
External IDs	Template:OMIM5 Template:MGI HomoloGene: 37912
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Caspase 3 is a caspase protein. It interacts with caspase 8.

This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes that undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7, and 9; and the protein itself is processed by caspases 8, 9, and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein.

Signaling pathway of TNF-R1. Dashed grey lines represent multiple steps

Further reading

• Cohen GM (1997). "Caspases: the executioners of apoptosis". Biochem. J. 326 ( Pt 1): 1–16. PMID 9337844.
• Roig J, Traugh JA (2001). "Cytostatic p21 G protein-activated protein kinase gamma-PAK". Vitam. Horm. 62: 167–98. PMID 11345898.
• Zhao LJ, Zhu H (2005). "Structure and function of HIV-1 auxiliary regulatory protein Vpr: novel clues to drug design". Curr. Drug Targets Immune Endocr. Metabol. Disord. 4 (4): 265–75. PMID 15578977.
• Le Rouzic E, Benichou S (2006). "The Vpr protein from HIV-1: distinct roles along the viral life cycle". Retrovirology. 2: 11. doi:10.1186/1742-4690-2-11. PMID 15725353.
• Sykes MC, Mowbray AL, Jo H (2007). "Reversible glutathiolation of caspase-3 by glutaredoxin as a novel redox signaling mechanism in tumor necrosis factor-alpha-induced cell death". Circ. Res. 100 (2): 152–4. doi:10.1161/01.RES.0000258171.08020.72. PMID 17272816.CS1 maint: Multiple names: authors list (link)