Cefamandole description
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Description
Mandol® (Cefamandol (cefamandole) Nafate for Injection, USP) is a semisynthetic broad-spectrum cephalosporin antibiotic for parenteral administration. It is 5-thia-1-azabicyclo [4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(formyloxy)phenylacetyl]amino]-3-[[(1-methyl-1 H -tetrazol-5-yl)thio]methyl]-8-oxo-, monosodium salt, [6 R- [6(alpha),7(beta)( R *)]]. Cefamandol (cefamandole) has the empirical formula C 19 H 17 N 6 NaO 6S 2 representing a molecular weight of 512.49.
Mandol (cefamandole) also contains 63 mg sodium carbonate/g of cefamandol (cefamandole) activity. The total sodium content is approximately 77 mg (3.3 mEq sodium ion) per g of cefamandole activity. After addition of diluent, cefamandole nafate rapidly hydrolyzes to cefamandol (cefamandole), and both compounds have microbiologic activity in vivo.
Solutions of Mandol (cefamandole) range from light-yellow to amber, depending on concentration and diluent used. The pH of freshly reconstituted solutions usually ranges from 6.0 to 8.5.[1]
References
- ↑ "http://www.rxlist.com/mandol-drug.htm". External link in
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Adapted from the FDA Package Insert.