Cephalexin detailed information

Cephalexin detailed information

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Clinical data
Pregnancy category	AU: A US: B (No risk in non-human studies)
Routes of administration	Oral
ATC code	J01DB01 (WHO)
Legal status
Legal status	AU: S4 (Prescription only) UK: POM (Prescription only)
Pharmacokinetic data
Bioavailability	Well absorbed
Metabolism	90% excreted unchanged
Elimination half-life	0.9 hours
Excretion	Renal
Identifiers
IUPAC name (6R,7R)-7-{[(2R)-2-amino-2-phenylacetyl]amino}- 3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene- 2-carboxylic acid
CAS Number	15686-71-2
PubChem CID	2666
DrugBank	APRD00250
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}
Chemical and physical data
Formula	C16H17N3O4S
Molar mass	347.39 g/mol

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Cefalexin (INN) (Template:PronEng) or cephalexin (USAN) is a first-generation cephalosporin antibiotic. It is an orally administered agent with a similar antimicrobial spectrum to the intravenous agents cefalotin and cefazolin. It is commonly marketed under the trade name Keflex (Lilly) or Sporidex (Ranbaxy).

Clinical use

Main article: Cephalosporin

Indications

Cefalexin is used to treat urinary tract infections, respiratory tract infections (including sinusitis, otitis media, pharyngitis, tonsillitis and pneumonia, bronchitis), skin and soft tissue infections.

Although it is not generally considered first-line treatment for any indication, it is a useful alternative to penicillins in patients with penicillin hypersensitivity. There is, however, cross-reactivity in 10% of patients with hypersensitivity to penicillins and carbapenems.

Formulations

Cefalexin is commonly marketed as tablets(250 mg and 500 mg), capsules, and powder for oral suspension (125 mg and 250 mg).

It is marketed by generic pharmaceutical manufacturers under a wide range of brand names, including: Apo-Cephalex, Biocef, Cefanox, Ceporex, Cephabos, Cilex, Ialex, Ibilex, Kefexin, Keflet, Keflex, Keforal, Keftab, Keftal, Lopilexin, Novo-Lexin, Ospexin, Zephalexin, Panixine Disperdose and Sporidex.

A version of Keflex 750 mg capsules is marketed for twice-daily dosage, to improve patients' compliance. However, it is not a sustained release formulation, and since it is more expensive than the older strengths, some physicians prescribe three 250 mg capsules to be taken twice daily, as a cheaper alternative.

External links

• MedlinePlus Drug Information: Cephalosporins (systemic) – information from USP DI Advice for the Patient
• FDA Drug Information PDF and Pharmacy Drug Information Insert.