Chandipura virus

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Chandipura virus is a member of the Rhabdoviridae family that is associated with an encephalitic illness in humans. It was first identified in 1965 after isolation from the blood of two patients from Chandipura village in Maharashtra state, India (Bhatt et al,1967) and has been associated with a number of otherwise unexplained outbreaks of encephalitic illness in central India. The most recent occurred in Andhra Pradesh and Maharashtra in June-August of 2003 with 329 children affected and 183 deaths. Further sporadic cases and deaths in children were observed in Gujarat state in 2004.

Chandipura virus has been isolated from sandflies in India and West Africa (Fontenille et al, 1994) and is probably spread through its bite. The presence of the virus in Africa indicates a wide distribution although no human cases have been observed outside of India.

The significance of Chandipura virus as a human pathogen is unresolved due to doubts over its role in the 2003 and 2004 outbreaks.