Chemerin peptide

retinoic acid receptor responder (tazarotene induced) 2
Identifiers
Symbol	RARRES2
Alt. symbols	chemerin
Entrez	5919
HUGO	9868
OMIM	601973
RefSeq	NM_002889
UniProt	Q99969
Other data
Locus	Chr. 7 q36.1

Chemerin Peptides are short peptides (on the order of 9 amino acids) that are produced from the carboxyl terminus of the chemokine chemerin. They display the same activities as chemerin, although at higher efficacy and potency.

A particular synthetic chemerin-derived peptide, termed C15, was developed at Oxford University. It showed anti-inflammatory activities. Intraperitoneal administration of C15 (0.32 ng/kg) to mice before zymosan challenge conferred significant protection against zymosan-induced peritonitis, suppressing neutrophil (63%) and monocyte (62%) recruitment with a concomitant reduction in proinflammatory mediator expression.

C15 was found to promote phagocytosis and efferocytosis in peritoneal macrophages at picomolar concentrations. C15 enhanced macrophage clearance of microbial particles and apoptotic cells by factor of 360% in vitro

See also

• Chemerin
• CMKLR1
• Chemokine
• Efferocytosis