Chlortetracycline

Chlortetracycline

Clinical data
Routes of administration	Oral, IV, topical
ATC code	D06AA02 (WHO) A01AB21 (WHO)
Pharmacokinetic data
Bioavailability	30%
Protein binding	50 to 55%
Metabolism	Hepatic (75%)
Elimination half-life	5.6 to 9 hours
Excretion	Renal and biliary
Identifiers
IUPAC name (2Z,4S,4aS,5aS,6S,12aS)-2-(amino-hydroxy- methylidene)-7-chloro-4-dimethylamino-6,10,11,12a- tetrahydroxy-6-methyl-4,4a,5,5a-tetrahydrotetracene- 1,3,12-trione
CAS Number	57-62-5
PubChem CID	5280963
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}
Chemical and physical data
Formula	C22H23ClN2O8
Molar mass	478.879 g/mol

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Chlortetracycline (trade name Aureomycin®, Lederle) is a tetracycline antibiotic, and was the first tetracycline to be discovered. It was discovered in 1945 by Dr Benjamin Duggar in a soil sample from Sanborn Field at the University of Missouri, yielding an actinomycete, Streptomyces aureofaciens (hence the name Aureomycin). In veterinary medicine, it is commonly used to treat conjunctivitis in cats.