Cholangiocarcinoma classification
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Farima Kahe M.D. [2] [3], Suveenkrishna Pothuru, M.B,B.S. [4]
Overview
Cholangiocarcinoma may be classified according to location of the tumor into three subtypes of Intrahepatic bile duct cancer, perihilar bile duct cancer, and extrahepatic bile duct cancer.
Classification
- Cholangiocarcinoma may be classified according to location of the tumor into three subtypes:[1][2][3]
- Intrahepatic bile duct cancer
- Perihilar bile duct cancer
- Extrahepatic bile duct cancer
Cellular Classification of Cholangiocarcinoma
Intrahepatic Bile Duct Cancer
- Mass-forming tumor growth pattern
- Periductal-infiltrating tumor growth pattern
- Mixed mass-forming and periductal-infiltrating growth pattern
Perihilar Bile Duct Cancer
- Carcinoma in situ
- Adenocarcinoma
- Intestinal type
- Mucinous type
- Clear cell type
- Signet-ring cell carcinoma
- Adenosquamous carcinoma
- Squamous cell carcinoma
- Small cell (oat cell) carcinoma
- Undifferentiated carcinoma
- Spindle cell type
- Giant cell type
- Small cell type
- Papillomatosis
- Papillary carcinoma
- Carcinoma, NOS
Extrahepatic Bile Duct Cancer
- Carcinoma in situ
- Adenocarcinoma, not otherwise specified (NOS)
- Adenocarcinoma
- Intestinal type
- Mucinous type
- Clear cell type
- Signet-ring cell carcinoma
- Adenosquamous carcinoma
- Squamous cell carcinoma
- Small cell (oat cell) carcinoma
- Undifferentiated carcinoma
- Spindle cell type
- Giant cell type
- Small cell type
- Papillomatosis
- Papillary carcinoma
- Noninvasive
- Papillary carcinoma
Bismuth-Corlette classification
- Type I: Tumors are distal to the hepatic duct confluence
- Type II: Neoplasms extend to and involve the hepatic duct confluence
- Type IIIA: Tumors involve the hepatic duct confluence and either the proximal right hepatic duct
- Type IIIB: Tumors involve the hepatic duct confluence and either the proximal left hepatic duct
- Type IV: Tumors extend into the bilateral proximal hepatic ducts up to the segmental bile ducts
References
- ↑ DeOliveira ML, Cunningham SC, Cameron JL, Kamangar F, Winter JM, Lillemoe KD, Choti MA, Yeo CJ, Schulick RD (2007). "Cholangiocarcinoma: thirty-one-year experience with 564 patients at a single institution". Ann. Surg. 245 (5): 755–62. doi:10.1097/01.sla.0000251366.62632.d3. PMC 1877058. PMID 17457168.
- ↑ Aishima S, Oda Y (2015). "Pathogenesis and classification of intrahepatic cholangiocarcinoma: different characters of perihilar large duct type versus peripheral small duct type". J Hepatobiliary Pancreat Sci. 22 (2): 94–100. doi:10.1002/jhbp.154. PMID 25181580.
- ↑ Oliveira IS, Kilcoyne A, Everett JM, Mino-Kenudson M, Harisinghani MG, Ganesan K (2017). "Cholangiocarcinoma: classification, diagnosis, staging, imaging features, and management". Abdom Radiol (NY). 42 (6): 1637–1649. doi:10.1007/s00261-017-1094-7. PMID 28271275.