Chorionic gonadotropin alpha

Glycoprotein hormones, alpha polypeptide
PDB rendering based on 1dz7.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1dz7​, 1e9j​, 1fl7​, 1hcn​, 1hd4​, 1hrp​, 1qfw​, 1xwd​
Identifiers
Symbols	CGA ; CG-ALPHA; FSHA; GPHA1; GPHa; HCG; LHA; TSHA
External IDs	Template:OMIM5 Template:MGI HomoloGene: 587
Gene ontology Molecular function Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Glycoprotein hormones, alpha polypeptide, also known as CGA, is a human gene.

The four human glycoprotein hormones chorionic gonadotropin (CG), luteinizing hormone (LH), follicle stimulating hormone (FSH), and thyroid stimulating hormone (TSH) are dimers consisting of alpha and beta subunits that are associated noncovalently. The alpha subunits of these hormones are identical, however, their beta chains are unique and confer biological specificity. The protein encoded by this gene is the alpha subunit and belongs to the glycoprotein hormones alpha chain family.

Further reading

• Roger M, Lahlou N, Couzinet B; et al. (1990). "[Free alpha-subunit glycoprotein hormones: physiological and pathological data]". J. Steroid Biochem. 33 (4B): 763–9. PMID 2481154.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Pierce JG (1972). "Eli Lilly lecture. The subunits of pituitary thyrotropin--their relationship to other glycoprotein hormones". Endocrinology. 89 (6): 1331–44. PMID 5002675.
• Kourides IA, Gurr JA, Wolf O (1984). "The regulation and organization of thyroid stimulating hormone genes". Recent Prog. Horm. Res. 40: 79–120. PMID 6207569.CS1 maint: Multiple names: authors list (link)
• Miyoshi I, Kasai N, Hayashizaki Y (1994). "[Structure and regulation of human thyroid-stimulating hormone (TSH) gene]". Nippon Rinsho. 52 (4): 940–7. PMID 8196184.CS1 maint: Multiple names: authors list (link)
• Barrios-De-Tomasi J, Timossi C, Merchant H; et al. (2002). "Assessment of the in vitro and in vivo biological activities of the human follicle-stimulating isohormones". Mol. Cell. Endocrinol. 186 (2): 189–98. PMID 11900895.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Moyle WR, Bahl OP, März L (1976). "Role of carbohydrate of human chorionic gonadotropin in the mechanism of hormone action". J. Biol. Chem. 250 (23): 9163–9. PMID 172504.CS1 maint: Multiple names: authors list (link)
• Fiddes JC, Goodman HM (1979). "Isolation, cloning and sequence analysis of the cDNA for the alpha-subunit of human chorionic gonadotropin". Nature. 281 (5730): 351–6. PMID 481597.
• Sairam MR, Li CH (1977). "Human pituitary thyrotropin. The primary structure of the alpha and beta subunits". Can. J. Biochem. 55 (7): 755–60. PMID 890569.
• Morgan FJ, Birken S, Canfield RE (1975). "The amino acid sequence of human chorionic gonadotropin. The alpha subunit and beta subunit". J. Biol. Chem. 250 (13): 5247–58. PMID 1150658.CS1 maint: Multiple names: authors list (link)
• Rathnam P, Saxena BB (1975). "Primary amino acid sequence of follicle-stimulating hormone from human pituitary glands. I. alpha subunit". J. Biol. Chem. 250 (17): 6735–46. PMID 1158880.
• Weisshaar G, Hiyama J, Renwick AG, Nimtz M (1991). "NMR investigations of the N-linked oligosaccharides at individual glycosylation sites of human lutropin". Eur. J. Biochem. 195 (1): 257–68. PMID 1991473.CS1 maint: Multiple names: authors list (link)
• Sakakibara R, Yokoo Y, Yoshikoshi K; et al. (1988). "Subcellular localization of intracellular forms of human chorionic gonadotropin in first trimester placenta". J. Biochem. 102 (5): 993–1001. PMID 2449427.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Matzuk MM, Keene JL, Boime I (1989). "Site specificity of the chorionic gonadotropin N-linked oligosaccharides in signal transduction". J. Biol. Chem. 264 (5): 2409–14. PMID 2536708.CS1 maint: Multiple names: authors list (link)
• Lustbader JW, Birken S, Pileggi NF; et al. (1990). "Crystallization and characterization of human chorionic gonadotropin in chemically deglycosylated and enzymatically desialylated states". Biochemistry. 28 (24): 9239–43. PMID 2611225.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Harris DC, Machin KJ, Evin GM; et al. (1989). "Preliminary X-ray diffraction analysis of human chorionic gonadotropin". J. Biol. Chem. 264 (12): 6705–6. PMID 2708337.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hayashizaki Y, Miyai K, Kato K, Matsubara K (1985). "Molecular cloning of the human thyrotropin-beta subunit gene". FEBS Lett. 188 (2): 394–400. PMID 3839756.CS1 maint: Multiple names: authors list (link)
• Bellisario R, Carlsen RB, Bahl OP (1973). "Human chorionic gonadotropin. Linear amino acid sequence of the alpha subunit". J. Biol. Chem. 248 (19): 6796–809. PMID 4745444.CS1 maint: Multiple names: authors list (link)
• Shome B, Parlow AF (1974). "Human follicle stimulating hormone (hFSH): first proposal for the amino acid sequence of the alpha-subunit (hFSHa) and first demonstration of its identity with the alpha-subunit of human luteinizing hormone (hLHa)". J. Clin. Endocrinol. Metab. 39 (1): 199–202. PMID 4835135.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.