Chromatin target of PRMT1 is a protein that in humans is encoded by the CHTOP gene .[1]
Function This gene encodes a small nuclear protein that is characterized by a arginine and glycine rich region. The encoded protein may be involved in cell cycle progression. This protein interacts with protein arginine methyltransferases and plays a role in the activation of estradiol-dependent transcription. Alternate splicing results in multiple transcript variants.
References Further reading
Zullo AJ, Michaud M, Zhang W, Grusby MJ (May 2009). "Identification of the small protein rich in arginine and glycine (SRAG): a newly identified nucleolar protein that can regulate cell proliferation" . The Journal of Biological Chemistry . 284 (18): 12504–11. doi :10.1074/jbc.M809436200 . PMC 2673316 PMID 19254951 . Chang CT, Hautbergue GM, Walsh MJ, Viphakone N, van Dijk TB, Philipsen S, Wilson SA (February 2013). "Chtop is a component of the dynamic TREX mRNA export complex" . The EMBO Journal . 32 (3): 473–86. doi :10.1038/emboj.2012.342 . PMC 3567497 PMID 23299939 . Teng IF, Wilson SA (2013). "Mapping interactions between mRNA export factors in living cells" . PLOS One . 8 (6): e67676. doi :10.1371/journal.pone.0067676 . PMC 3691119 PMID 23826332 . van Dijk TB, Gillemans N, Stein C, Fanis P, Demmers J, van de Corput M, Essers J, Grosveld F, Bauer UM, Philipsen S (January 2010). "Friend of Prmt1, a novel chromatin target of protein arginine methyltransferases" . Molecular and Cellular Biology . 30 (1): 260–72. doi :10.1128/MCB.00645-09 . PMC 2798285 PMID 19858291 . van Dijk TB, Gillemans N, Pourfarzad F, van Lom K, von Lindern M, Grosveld F, Philipsen S (November 2010). "Fetal globin expression is regulated by Friend of Prmt1" . Blood . 116 (20): 4349–52. doi :10.1182/blood-2010-03-274399 . PMC 2993632 PMID 20688955 .
This article incorporates text from the United States National Library of Medicine , which is in the public domain .
