Clindamycin palmitate hydrochloride description
| Clindamycin palmitate hydrochloride |
|---|
| CLINDAMYCIN PALMITATE HYDROCHLORIDE® FDA Package Insert |
| Description |
| Clinical Pharmacology |
| Microbiology |
| Indications and Usage |
| Contraindications |
| Warnings |
| Precautions |
| Adverse Reactions |
| Overdosage |
| Dosage and Administration |
| How Supplied |
| Labels and Packages |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Abdurahman Khalil, M.D. [2]
DESCRIPTION
Clindamycin palmitate hydrochloride is a water soluble hydrochloride salt of the ester of clindamycin and palmitic acid. Clindamycin is a semisynthetic antibiotic produced by a 7(S)-chloro-substitution of the 7(R)-hydroxyl group of the parent compound lincomycin.
The structural formula is represented below:
The chemical name for clindamycin palmitate hydrochloride is Methyl 7-chloro-6, 7, 8-trideoxy-6-(1-methyl-trans-4-propyl-L-2-pyrrolidinecarboxamido)-1-thio-L-threo-α-D-galacto-octopyranoside 2-palmitate monohydrochloride.
Clindamycin palmitate hydrochloride for oral solution, USP (Pediatric) flavored granules contains clindamycin palmitate hydrochloride for reconstitution. The drug powder appears as a white to off-white powder. The reconstituted solution appears as a clear to slightly hazy solution with no significant precipitate.
Each 5 mL contains the equivalent of 75 mg clindamycin. Inactive ingredients: natural cherry flavor, dextrin, ethylparaben, poloxamer 188, simethicone, sucrose.
References
http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=e1cb8caa-1e49-41e7-bbd8-a2e75bea2fe4