Collagen alpha-1(XV) chain is a protein that in humans is encoded by the COL15A1gene.[1][2]
This gene encodes the alpha chain of type XV collagen, a member of the FACIT collagen family (fibril-associated collagens with interrupted helices). Type XV collagen has a wide tissue distribution but the strongest expression is localized to basement membrane zones so it may function to adhere basement membranes to underlying connective tissue stroma. Mouse studies have shown that collagen XV deficiency is associated with muscle and microvessel deterioration.[2]
References
↑Huebner K, Cannizzaro LA, Jabs EW, Kivirikko S, Manzone H, Pihlajaniemi T, Myers JC (Dec 1992). "Chromosomal assignment of a gene encoding a new collagen type (COL15A1) to 9q21 --> q22". Genomics. 14 (2): 220–4. doi:10.1016/S0888-7543(05)80209-5. PMID1427836.
Kivirikko S, Heinämäki P, Rehn M, et al. (1994). "Primary structure of the alpha 1 chain of human type XV collagen and exon-intron organization in the 3' region of the corresponding gene". J. Biol. Chem. 269 (7): 4773–9. PMID8106446.
Muragaki Y, Abe N, Ninomiya Y, et al. (1994). "The human alpha 1(XV) collagen chain contains a large amino-terminal non-triple helical domain with a tandem repeat structure and homology to alpha 1(XVIII) collagen". J. Biol. Chem. 269 (6): 4042–6. PMID8307960.
Myers JC, Dion AS, Abraham V, Amenta PS (1997). "Type XV collagen exhibits a widespread distribution in human tissues but a distinct localization in basement membrane zones". Cell Tissue Res. 286 (3): 493–505. doi:10.1007/s004410050719. PMID8929352.
Hägg PM, Muona A, Liétard J, et al. (1998). "Complete exon-intron organization of the human gene for the alpha1 chain of type XV collagen (COL15A1) and comparison with the homologous COL18A1 gene". J. Biol. Chem. 273 (28): 17824–31. doi:10.1074/jbc.273.28.17824. PMID9651385.
Ramchandran R, Dhanabal M, Volk R, et al. (1999). "Antiangiogenic activity of restin, NC10 domain of human collagen XV: comparison to endostatin". Biochem. Biophys. Res. Commun. 255 (3): 735–9. doi:10.1006/bbrc.1999.0248. PMID10049780.
Li D, Clark CC, Myers JC (2000). "Basement membrane zone type XV collagen is a disulfide-bonded chondroitin sulfate proteoglycan in human tissues and cultured cells". J. Biol. Chem. 275 (29): 22339–47. doi:10.1074/jbc.M000519200. PMID10791950.
Nishi M, Mizushima A, Nakagawara K, Takeshima H (2000). "Characterization of human junctophilin subtype genes". Biochem. Biophys. Res. Commun. 273 (3): 920–7. doi:10.1006/bbrc.2000.3011. PMID10891348.
Eklund L, Muona A, Liétard J, Pihlajaniemi T (2001). "Structure of the mouse type XV collagen gene, Col15a1, comparison with the human COL15A1 gene and functional analysis of the promoters of both genes". Matrix Biol. 19 (6): 489–500. doi:10.1016/S0945-053X(00)00090-1. PMID11068203.
Tomono Y, Naito I, Ando K, et al. (2002). "Epitope-defined monoclonal antibodies against multiplexin collagens demonstrate that type XV and XVIII collagens are expressed in specialized basement membranes". Cell Struct. Funct. 27 (1): 9–20. doi:10.1247/csf.27.9. PMID11937714.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID14702039.
