Congenital hemolytic anemia

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Synonyms and keywords: Hereditary hemolytic anemia

Overview

Congenital hemolytic anemia refers to hemolytic anemia which is primarily due to congenital disorders.

Classification

Types include:

• Genetic conditions of the RBC membrane:
  • Hereditary spherocytosis
  • Hereditary elliptocytosis
• Genetic conditions of RBC metabolism (enzyme defects):
  • Glucose-6-phosphate dehydrogenase deficiency (G6PD or favism)
  • Pyruvate kinase deficiency
• Hemoglobinopathies/genetic conditions of hemoglobin:
  • Sickle cell anemia
  • Thalassaemia