Congenital rubella syndrome differential diagnosis
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Dima Nimri, M.D. [2]
Overview
The most important congenital infections, which can be transmitted vertically from mother to fetus are the TORCH infections. These infections have overlapping features and hence, must be differentiated from CRS.[1][2]
Differentiating Congenital Rubella Syndrome from other Diseases
The most important congenital infections, which can be transmitted vertically from mother to fetus are the TORCH infections. These infections have overlapping features and hence, must be differentiated from CRS:[1][2]
| Congenital Infection | Cardiac Findings | Skin Findings | Ocular Findings | Hepatosplenomegaly | Hydrocephaly | Microcephaly | Intracranial Calcifications | Hearing deficits |
|---|---|---|---|---|---|---|---|---|
| Toxoplasmosis | — | ✔ | ✔ | ✔ | Diffuse intracranial calcifications | — | ||
| Treponema pallidum | — | ✔ | — | — | — | — | ||
| Rubella | ✔ | ✔ | ✔ | — | ✔ | |||
| Cytomegalovirus (CMV) | ✔ | ✔ | — | ✔ | Periventricular calcifications | ✔ | ||
| Herpes simplex virus (HSV) | ✔ | ✔ | ✔ | — | ✔ | |||
| Parvovirus B19 | ✔ | — | — | — | — |
References
- ↑ 1.0 1.1 Neu N, Duchon J, Zachariah P (2015). "TORCH infections". Clin Perinatol. 42 (1): 77–103, viii. doi:10.1016/j.clp.2014.11.001. PMID 25677998.
- ↑ 2.0 2.1 Ajij M, Nangia S, Dubey BS (2014). "Congenital rubella syndrome with blueberry muffin lesions and extensive metaphysitis". J Clin Diagn Res. 8 (12): PD03–4. doi:10.7860/JCDR/2014/10271.5293. PMC 4316306. PMID 25654000.