Copine 3

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Identifiers
Aliases
External IDs	GeneCards: [1]
Orthologs
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a
Wikidata
View/Edit Human

Copine 3 is a protein that in humans is encoded by the CPNE3 gene.

Function

Calcium-dependent membrane-binding proteins may regulate molecular events at the interface of the cell membrane and cytoplasm. This gene encodes a protein which contains two type II C2 domains in the amino-terminus and an A domain-like sequence in the carboxy-terminus. The A domain mediates interactions between integrins and extracellular ligands. [provided by RefSeq, Aug 2008].

Further reading

• Thomas G, Jacobs KB, Yeager M, Kraft P, Wacholder S, Orr N, Yu K, Chatterjee N, Welch R, Hutchinson A, Crenshaw A, Cancel-Tassin G, Staats BJ, Wang Z, Gonzalez-Bosquet J, Fang J, Deng X, Berndt SI, Calle EE, Feigelson HS, Thun MJ, Rodriguez C, Albanes D, Virtamo J, Weinstein S, Schumacher FR, Giovannucci E, Willett WC, Cussenot O, Valeri A, Andriole GL, Crawford ED, Tucker M, Gerhard DS, Fraumeni JF, Hoover R, Hayes RB, Hunter DJ, Chanock SJ (2008). "Multiple loci identified in a genome-wide association study of prostate cancer". Nat. Genet. 40 (3): 310–5. doi:10.1038/ng.91. PMID 18264096.
• Thomas G, Jacobs KB, Yeager M, Kraft P, Wacholder S, Orr N, Yu K, Chatterjee N, Welch R, Hutchinson A, Crenshaw A, Cancel-Tassin G, Staats BJ, Wang Z, Gonzalez-Bosquet J, Fang J, Deng X, Berndt SI, Calle EE, Feigelson HS, Thun MJ, Rodriguez C, Albanes D, Virtamo J, Weinstein S, Schumacher FR, Giovannucci E, Willett WC, Cussenot O, Valeri A, Andriole GL, Crawford ED, Tucker M, Gerhard DS, Fraumeni JF, Hoover R, Hayes RB, Hunter DJ, Chanock SJ (2008). "Multiple loci identified in a genome-wide association study of prostate cancer". Nat. Genet. 40 (3): 310–5. doi:10.1038/ng.91. PMID 18264096.
• Heinrich C, Keller C, Boulay A, Vecchi M, Bianchi M, Sack R, Lienhard S, Duss S, Hofsteenge J, Hynes NE (2010). "Copine-III interacts with ErbB2 and promotes tumor cell migration". Oncogene. 29 (11): 1598–610. doi:10.1038/onc.2009.456. PMID 20010870.
• Cohen OS, Mccoy SY, Middleton FA, Bialosuknia S, Zhang-James Y, Liu L, Tsuang MT, Faraone SV, Glatt SJ (2012). "Transcriptomic analysis of postmortem brain identifies dysregulated splicing events in novel candidate genes for schizophrenia". Schizophr. Res. 142 (1–3): 188–99. doi:10.1016/j.schres.2012.09.015. PMC 3502694. PMID 23062752.
• Lin HC, Zhang FL, Geng Q, Yu T, Cui YQ, Liu XH, Li J, Yan MX, Liu L, He XH, Li JJ, Yao M (2013). "Quantitative proteomic analysis identifies CPNE3 as a novel metastasis-promoting gene in NSCLC". J. Proteome Res. 12 (7): 3423–33. doi:10.1021/pr400273z. PMID 23713811.
• Choi HY, Park N, Na JB, Ko ES, Park JY, Yoo JC (2016). "Direct binding of Copine3 with Jab1 activates downstream ErbB2 signaling and motility in SKBr3 breast cancer cells". Oncol. Rep. 35 (2): 1147–52. doi:10.3892/or.2015.4472. PMID 26719032.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.