Crohn's disease epidemiology and demographics
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] ; Associate Editor(s)-in-Chief: Aditya Ganti M.B.B.S. [2]
Overview
The incidence of Crohn's disease has been ascertained from population studies in Norway and the United States and is similar at 6 to 7.1:100,000. Prevalence estimates for Northern Europe have ranged from 27–48 per 100,000. Crohn's disease tends to present initially in the teens and twenties, with another peak incidence in the fifties to seventies, although the disease can occur at any age. Crohn's disease affects between 400,000 and 600,000 people in North America. Crohn's disease has a bimodal distribution in incidence as a function of age. There is no association with gender, social class or occupation.
Epidemiology and Demographics
Prevalence
- Prevalence estimates for Northern Europe have ranged from 27–48 per 100,000.[1]
- Crohn's disease tends to present initially in the teens and twenties, with another peak incidence in the fifties to seventies, although the disease can occur at any age. Crohn's disease affects between 400,000 and 600,000 people in North America.[2]
Incidence
- The incidence of Crohn's disease has been ascertained from population studies in Norway and the United States and is similar at 6 to 7.1:100,000.[3][4]
- Crohn's disease is more common in northern countries, and shows a higher preponderance in northern areas of the same country.[5]
- The incidence of Crohn's disease in North America is 6 per 100,000 population and is similar in Europe, but the incidence rates are lower in Asia and Africa.
Demographics
Age
- Crohn's disease has a bimodal distribution in incidence as a function of age.
- The disease tends to strike people in their teens and twenties, and people in their fifties through seventies. It is rare in early childhood.
- Parents, siblings or children of people with Crohn's disease are 3 to 20 times more likely to develop the disease.[6]
- Twin studies show a concordance of greater than 55% for Crohn's disease.[7]
Gender
- There is no association with gender, social class or occupation.
Race
- Whites and European Jews accounted for the vast majority of the cases in the United States, and in most industrialized countries. [8]
References
- ↑ Bernstein, Charles N. "The Epidemiology of Inflammatory Bowel Disease in Canada: A Population-Based Study". The American Journal of Gastroenterology. 101 (7): 1559–1568. doi:10.1111/j.1572-0241.2006.00603.x. PMID 16863561.
- ↑ Loftus, E. V. "The epidemiology and natural history of Crohn's disease in population-based patient cohorts from North America: a systematic review". Alimentary Pharmacology & Therapeutics. 16 (1): 51–60. doi:10.1046/j.1365-2036.2002.01140.x. PMID 11856078.
- ↑ Hiatt, Robert A. "Epidemiology of inflammatory bowel disease in a defined northern California population". Western Journal of Medicine. 149 (5): 541–6. PMID 3250100. Retrieved 2006-07-02.
- ↑ Moum, B. "Incidence of Crohn's disease in four counties in southeastern Norway, 1990-93. A prospective population-based study. The Inflammatory Bowel South-Eastern Norway (IBSEN) Study Group of Gastroenterologists". Scandinavian Journal of Gastroenterology. 31 (4): 355–61. PMID 8726303.
- ↑ Shivananda, S. "Incidence of inflammatory bowel disease across Europe: is there a difference between north and south? Results of the European Collaborative Study on Inflammatory Bowel Disease (EC-IBD)". Gut. 39 (5): 690–7. PMID 9014768.
- ↑ Satsangi J, Jewell DP, Bell JI. The genetics of inflammatory bowel disease and they are sick and we too. Gut. 1997 May;40(5):572-4. PMID 9203931.
- ↑ Tysk C, Lindberg E, Jarnerot G, Floderus-Myrhed B. Ulcerative colitis and Crohn's disease in an unselected population of monozygotic and dizygotic twins. A study of heritability and the influence of smoking. Gut 1988 Jul;29(7):990-6. PMID 3396969
- ↑ Podolsky, Daniel K. "Inflammatory bowel disease". New England Journal of Medicine. 346 (6): 417–29. PMID 12167685. Retrieved 2006-07-02.