Cryoglobulinemia history and symptoms

	Cryoglobulinemia Microchapters
Home
Patient Information
Overview
Historical Perspective
Classification
Pathophysiology
Causes
Differentiating Cryoglobulinemia from other Diseases
Epidemiology and Demographics
Risk Factors
Screening
Natural History, Complications and Prognosis
Diagnosis
Diagnostic Study of Choice
History and Symptoms
Physical Examination
Laboratory Findings
Electrocardiogram
X Ray
CT
MRI
Ultrasound
Other Imaging Findings
Other Diagnostic Studies
Treatment
Medical Therapy
Surgery
Primary Prevention
Secondary Prevention
Cost-Effectiveness of Therapy
Future or Investigational Therapies
Case Studies
Case #1
Cryoglobulinemia history and symptoms On the Web
Most recent articles
Most cited articles
Review articles
CME Programs
Powerpoint slides
Images
American Roentgen Ray Society Images of Cryoglobulinemia history and symptoms All Images X-rays Echo & Ultrasound CT Images MRI
Ongoing Trials at Clinical Trials.gov
US National Guidelines Clearinghouse
NICE Guidance
FDA on Cryoglobulinemia history and symptoms
CDC on Cryoglobulinemia history and symptoms
Cryoglobulinemia history and symptoms in the news
Blogs on Cryoglobulinemia history and symptoms
Directions to Hospitals Treating Cryoglobulinemia
Risk calculators and risk factors for Cryoglobulinemia history and symptoms

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Cafer Zorkun, M.D., Ph.D. [2]Feham Tariq, MD [3]

Overview

Patients having cryoglobulinemia may have positive history of hepatitis C infection, hepatitis B infection, leg ulcers or recurrent thrombosis. Symptoms vary depending on the type of cryoglobulinemia and the organs involved.

History

Patients having cryoglobulinemia may have positive history of:

Hepatitis C infection
Hepatitis B infection
Leg ulcers
Recurrent thrombosis

Symptoms

Symptoms vary depending on the type of cryoglobulinemia and the organs involved. Symptoms of cryoglobulinemia may include:^[1]^[2]^[3]

Pulmonary symptoms:

Difficulty breathing and cough

Renal symptoms:

Renal involvement is more common in type II than in type III.
Nephrotic range proteinuria with edema

Cutaneous symptoms:

Purpura or skin ulcer

Gastrointestinal symptoms

Abdominal pain

General symptoms:

Nonspecific constitutional symptoms
Fever
Arthralgia, specifically affecting metacarophangeal, proximal phalangeal, knees and ankles. It worsens with exposure to the cold.
Myalgia
Fatigue

Blurring/loss of vision
Diplopia
Confusion

References

↑ Brouet JC, Clauvel JP, Danon F, Klein M, Seligmann M (1974). "Biologic and clinical significance of cryoglobulins. A report of 86 cases". Am J Med. 57 (5): 775–88. PMID 4216269.
↑ Monti G, Galli M, Invernizzi F, Pioltelli P, Saccardo F, Monteverde A; et al. (1995). "Cryoglobulinaemias: a multi-centre study of the early clinical and laboratory manifestations of primary and secondary disease. GISC. Italian Group for the Study of Cryoglobulinaemias". QJM. 88 (2): 115–26. PMID 7704562.
↑ Ramos-Casals M, Trejo O, García-Carrasco M, Cervera R, Font J (2000). "Mixed cryoglobulinemia: new concepts". Lupus. 9 (2): 83–91. doi:10.1191/096120300678828127. PMID 10787003.

Template:WikiDoc Sources

[pmid4216269-1] Brouet JC, Clauvel JP, Danon F, Klein M, Seligmann M (1974). "Biologic and clinical significance of cryoglobulins. A report of 86 cases". Am J Med. 57 (5): 775–88. PMID 4216269.

[pmid7704562-2] Monti G, Galli M, Invernizzi F, Pioltelli P, Saccardo F, Monteverde A; et al. (1995). "Cryoglobulinaemias: a multi-centre study of the early clinical and laboratory manifestations of primary and secondary disease. GISC. Italian Group for the Study of Cryoglobulinaemias". QJM. 88 (2): 115–26. PMID 7704562.

[pmid10787003-3] Ramos-Casals M, Trejo O, García-Carrasco M, Cervera R, Font J (2000). "Mixed cryoglobulinemia: new concepts". Lupus. 9 (2): 83–91. doi:10.1191/096120300678828127. PMID 10787003.

[1]

[2]

[3]