Cycloguanil

Cycloguanil

Clinical data
ATC code	P01BB02 (WHO)
Identifiers
IUPAC name 1-(4-chlorophenyl)-6,6-dimethyl-1,3,5-triazine-2,4-diamine
CAS Number	516-21-2 Y
PubChem CID	9049
ChemSpider	8697 Y
UNII	26RM326WVN
ChEMBL	ChEMBL747 Y
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}
Chemical and physical data
Formula	C11H14ClN5
Molar mass	251.715 g/mol
3D model (JSmol)	Interactive image
SMILES Clc1ccc(cc1)N2C(=N/C(=N\C2(C)C)N)\N
InChI InChI=1S/C11H14ClN5/c1-11(2)16-9(13)15-10(14)17(11)8-5-3-7(12)4-6-8/h3-6H,1-2H3,(H4,13,14,15,16) Y Key:QMNFFXRFOJIOKZ-UHFFFAOYSA-N Y
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WikiDoc Resources for Cycloguanil
Articles
Most recent articles on Cycloguanil Most cited articles on Cycloguanil Review articles on Cycloguanil Articles on Cycloguanil in N Eng J Med, Lancet, BMJ
Media
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Evidence Based Medicine
Cochrane Collaboration on Cycloguanil Bandolier on Cycloguanil TRIP on Cycloguanil
Clinical Trials
Ongoing Trials on Cycloguanil at Clinical Trials.gov Trial results on Cycloguanil Clinical Trials on Cycloguanil at Google
Guidelines / Policies / Govt
US National Guidelines Clearinghouse on Cycloguanil NICE Guidance on Cycloguanil NHS PRODIGY Guidance FDA on Cycloguanil CDC on Cycloguanil
Books
Books on Cycloguanil
News
Cycloguanil in the news Be alerted to news on Cycloguanil News trends on Cycloguanil
Commentary
Blogs on Cycloguanil
Definitions
Definitions of Cycloguanil
Patient Resources / Community
Patient resources on Cycloguanil Discussion groups on Cycloguanil Patient Handouts on Cycloguanil Directions to Hospitals Treating Cycloguanil Risk calculators and risk factors for Cycloguanil
Healthcare Provider Resources
Symptoms of Cycloguanil Causes & Risk Factors for Cycloguanil Diagnostic studies for Cycloguanil Treatment of Cycloguanil
Continuing Medical Education (CME)
CME Programs on Cycloguanil
International
Cycloguanil en Espanol Cycloguanil en Francais
Business
Cycloguanil in the Marketplace Patents on Cycloguanil
Experimental / Informatics
List of terms related to Cycloguanil

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Cycloguanil is a dihydrofolate reductase inhibitor, and is a metabolite of the antimalarial drug proguanil; its formation in vivo has been thought to be primarily responsible for the antimalarial activity of proguanil. However, more recent work has indicated that, while proguanil is synergistic with the drug atovaquone (as in the combination Malarone), cycloguanil is in fact antagonistic to the effects of atovaquone, suggesting that, unlike cycloguanil, proguanil may have an alternative mechanism of antimalarial action besides dihydrofolate reductase inhibition.

Although cycloguanil is not currently in general use as an antimalarial, the continuing development of resistance to current antimalarial drugs has led to renewed interest in studying the use of cycloguanil in combination with other drugs.