Proguanil
File:Proguanil.svg | |
Clinical data | |
---|---|
ATC code | |
Pharmacokinetic data | |
Elimination half-life | ~20 h |
Identifiers | |
| |
CAS Number | |
PubChem CID | |
DrugBank | |
E number | {{#property:P628}} |
ECHA InfoCard | {{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value). |
Chemical and physical data | |
Formula | C11H16ClN5 |
Molar mass | 253.731 g/mol |
Proguanil (proguanil hydrochloride) is a prophylactic antimalarial drug, which works by stopping the malaria parasite, Plasmodium falciparum and Plasmodium vivax, from reproducing once it is in the red blood cells. It does this by inhibiting the enzyme, dihydrofolate reductase, which is involved in the reproduction of the parasite.
Proguanil is effective against sporozoites.
Proguanil is usually taken in combination with another anti-malarial drug such as atovaquone (e.g., in the drug Malarone) or chloroquine. Malarone has fewer side effects than mefloquine, but can be more expensive because it's taken daily. Proguanil is taken with Atovaquone for chloroquine-resistant and multidrug resistant strains of P. falciparum and P. vivax.
Proguanil also known as Paludrine (Astra Zeneca)
References
- Pages with script errors
- Pages with broken file links
- E number from Wikidata
- ECHA InfoCard ID from Wikidata
- Articles without EBI source
- Chemical pages without ChemSpiderID
- Articles without KEGG source
- Articles without InChI source
- Articles without UNII source
- Drugs with no legal status
- Articles containing unverified chemical infoboxes
- Antimicrobial stubs
- Dihydrofolate reductase inhibitors
- Antimalarial agents