In mammals, the Y chromosome directs the development of the testes and plays an important role in spermatogenesis. A high percentage of infertile men have deletions that map to regions of the Y chromosome. The DAZ1 (Deleted in Azoospermia) gene cluster maps to the AZFc region of the Y chromosome and is deleted in many azoospermic and severely oligospermic men. It is thought that the DAZ gene cluster arose from the transposition, amplification, and pruning of the ancestral autosomal gene DAZL also involved in germ cell development and gametogenesis. This gene encodes an RNA-binding protein with two RNP motifs that was originally identified by its interaction with the infertility factors DAZ and DAZL. Two isoforms are encoded by transcript variants of this gene.[2]
Interactions
DAZ associated protein 1 has been shown to interact with DAZ1.[3]
References
↑Tsui S, Dai T, Roettger S, Schempp W, Salido EC, Yen PH (August 2000). "Identification of two novel proteins that interact with germ-cell-specific RNA-binding proteins DAZ and DAZL1". Genomics. 65 (3): 266–73. doi:10.1006/geno.2000.6169. PMID10857750.
↑Tsui S, Dai T, Roettger S, Schempp W, Salido EC, Yen PH (May 2000). "Identification of two novel proteins that interact with germ-cell-specific RNA-binding proteins DAZ and DAZL1". Genomics. 65 (3): 266–73. doi:10.1006/geno.2000.6169. PMID10857750.
Vera Y, Dai T, Hikim AP, Lue Y, Salido EC, Swerdloff RS, Yen PH (2003). "Deleted in azoospermia associated protein 1 shuttles between nucleus and cytoplasm during normal germ cell maturation". J. Androl. 23 (5): 622–8. PMID12185095.
Prima V, Gore L, Caires A, Boomer T, Yoshinari M, Imaizumi M, Varella-Garcia M, Hunger SP (2005). "Cloning and functional characterization of MEF2D/DAZAP1 and DAZAP1/MEF2D fusion proteins created by a variant t(1;19)(q23;p13.3) in acute lymphoblastic leukemia". Leukemia. 19 (5): 806–13. doi:10.1038/sj.leu.2403684. PMID15744350.
Pan HA, Lin YS, Lee KH, Huang JR, Lin YH, Kuo PL (2006). "Expression patterns of the DAZ-associated protein DAZAP1 in rat and human ovaries". Fertil. Steril. 84 Suppl 2: 1089–94. doi:10.1016/j.fertnstert.2005.03.075. PMID16209998.
