DEFB4

Defensin, beta 4
PDB rendering based on 1e4q.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1e4q​, 1fd3​, 1fd4​, 1fqq​
Identifiers
Symbols	DEFB4 ; DEFB-2; DEFB102; DEFB2; HBD-2; SAP1
External IDs	Template:OMIM5 HomoloGene: 87854
Gene ontology Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Defensin, beta 4, also known as DEFB4, is a human gene.

Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Members of the defensin family are highly similar in protein sequence. This gene encodes defensin, beta 4, an antibiotic peptide which is locally regulated by inflammation.

Further reading

• Weinberg A, Krisanaprakornkit S, Dale BA (1999). "Epithelial antimicrobial peptides: review and significance for oral applications". Crit. Rev. Oral Biol. Med. 9 (4): 399–414. PMID 9825219.CS1 maint: Multiple names: authors list (link)
• Schröder JM, Harder J (1999). "Human beta-defensin-2". Int. J. Biochem. Cell Biol. 31 (6): 645–51. PMID 10404637.
• Harder J, Bartels J, Christophers E, Schröder JM (1997). "A peptide antibiotic from human skin". Nature. 387 (6636): 861. doi:10.1038/43088. PMID 9202117.CS1 maint: Multiple names: authors list (link)
• Bals R, Wang X, Wu Z; et al. (1998). "Human beta-defensin 2 is a salt-sensitive peptide antibiotic expressed in human lung". J. Clin. Invest. 102 (5): 874–80. PMID 9727055.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Liu L, Wang L, Jia HP; et al. (1999). "Structure and mapping of the human beta-defensin HBD-2 gene and its expression at sites of inflammation". Gene. 222 (2): 237–44. PMID 9831658.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mathews M, Jia HP, Guthmiller JM; et al. (1999). "Production of beta-defensin antimicrobial peptides by the oral mucosa and salivary glands". Infect. Immun. 67 (6): 2740–5. PMID 10338476.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Jia HP, Mills JN, Barahmand-Pour F; et al. (1999). "Molecular cloning and characterization of rat genes encoding homologues of human beta-defensins". Infect. Immun. 67 (9): 4827–33. PMID 10456937.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yang D, Chertov O, Bykovskaia SN; et al. (1999). "Beta-defensins: linking innate and adaptive immunity through dendritic and T cell CCR6". Science. 286 (5439): 525–8. PMID 10521347.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Diamond G, Kaiser V, Rhodes J; et al. (2000). "Transcriptional regulation of beta-defensin gene expression in tracheal epithelial cells". Infect. Immun. 68 (1): 113–9. PMID 10603376.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Harder J, Meyer-Hoffert U, Teran LM; et al. (2000). "Mucoid Pseudomonas aeruginosa, TNF-alpha, and IL-1beta, but not IL-6, induce human beta-defensin-2 in respiratory epithelia". Am. J. Respir. Cell Mol. Biol. 22 (6): 714–21. PMID 10837369.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hoover DM, Rajashankar KR, Blumenthal R; et al. (2000). "The structure of human beta-defensin-2 shows evidence of higher order oligomerization". J. Biol. Chem. 275 (42): 32911–8. doi:10.1074/jbc.M006098200. PMID 10906336.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Meyer JE, Harder J, Görögh T; et al. (2000). "[hBD-2 gene expression in nasal mucosa]". Laryngorhinootologie. 79 (7): 400–3. PMID 11005092.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ali RS, Falconer A, Ikram M; et al. (2001). "Expression of the peptide antibiotics human beta defensin-1 and human beta defensin-2 in normal human skin". J. Invest. Dermatol. 117 (1): 106–11. doi:10.1046/j.0022-202x.2001.01401.x. PMID 11442756.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Carothers DG, Graham SM, Jia HP; et al. (2001). "Production of beta-defensin antimicrobial peptides by maxillary sinus mucosa". American journal of rhinology. 15 (3): 175–9. PMID 11453504.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Biragyn A, Surenhu M, Yang D; et al. (2002). "Mediators of innate immunity that target immature, but not mature, dendritic cells induce antitumor immunity when genetically fused with nonimmunogenic tumor antigens". J. Immunol. 167 (11): 6644–53. PMID 11714836.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bauer F, Schweimer K, Klüver E; et al. (2002). "Structure determination of human and murine beta-defensins reveals structural conservation in the absence of significant sequence similarity". Protein Sci. 10 (12): 2470–9. PMID 11714914.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Takahashi A, Wada A, Ogushi K; et al. (2001). "Production of beta-defensin-2 by human colonic epithelial cells induced by Salmonella enteritidis flagella filament structural protein". FEBS Lett. 508 (3): 484–8. PMID 11728477.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Schibli DJ, Hunter HN, Aseyev V; et al. (2002). "The solution structures of the human beta-defensins lead to a better understanding of the potent bactericidal activity of HBD3 against Staphylococcus aureus". J. Biol. Chem. 277 (10): 8279–89. doi:10.1074/jbc.M108830200. PMID 11741980.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)