DHH (gene)

Desert hedgehog homolog (Drosophila)
Identifiers
Symbols	DHH ; HHG-3; MGC35145
External IDs	Template:OMIM5 Template:MGI HomoloGene: 22431
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Desert hedgehog homolog (Drosophila), also known as DHH, is a human gene.

This gene encodes a member of the Hedgehog family. The hedgehog gene family encodes signaling molecules that play an important role in regulating morphogenesis. This protein is predicted to be made as a precursor that is autocatalytically cleaved; the N-terminal portion is soluble and contains the signalling activity while the C-terminal portion is involved in precursor processing. More importantly, the C-terminal product covalently attaches a cholesterol moiety to the N-terminal product, restricting the N-terminal product to the cell surface and preventing it from freely diffusing throughout the organism. Defects in this protein have been associated with partial gonadal dysgenesis (PGD) accompanied by minifascicular polyneuropathy. This protein may be involved in both male gonadal differentiation and perineurial development.

Further reading

• Matsui Y (1998). "Regulation of germ cell death in mammalian gonads". APMIS. 106 (1): 142–7, discussion 147-8. PMID 9524572.
• Umehara F, Tate G, Itoh K, Osame M (2002). "Minifascicular neuropathy: a new concept of the human disease caused by desert hedgehog gene mutation". Cell. Mol. Biol. (Noisy-le-grand). 48 (2): 187–9. PMID 11990454.CS1 maint: Multiple names: authors list (link)
• Echelard Y, Epstein DJ, St-Jacques B; et al. (1994). "Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity". Cell. 75 (7): 1417–30. PMID 7916661.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bitgood MJ, Shen L, McMahon AP (1997). "Sertoli cell signaling by Desert hedgehog regulates the male germline". Curr. Biol. 6 (3): 298–304. PMID 8805249.CS1 maint: Multiple names: authors list (link)
• Carpenter D, Stone DM, Brush J; et al. (1998). "Characterization of two patched receptors for the vertebrate hedgehog protein family". Proc. Natl. Acad. Sci. U.S.A. 95 (23): 13630–4. PMID 9811851.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chuang PT, McMahon AP (1999). "Vertebrate Hedgehog signalling modulated by induction of a Hedgehog-binding protein". Nature. 397 (6720): 617–21. doi:10.1038/17611. PMID 10050855.
• Kamisago M, Kimura M, Furutani Y; et al. (2000). "Assignment of human desert hedgehog gene (DHH) to chromosome band 12q13.1 by in situ hybridization". Cytogenet. Cell Genet. 87 (1–2): 117–8. PMID 10640830.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tate G, Satoh H, Endo Y, Mitsuya T (2000). "Assignment of desert hedgehog (DHH) to human chromosome bands 12q12-->q13.1 by in situ hybridization". Cytogenet. Cell Genet. 88 (1–2): 93–4. PMID 10773676.CS1 maint: Multiple names: authors list (link)
• Umehara F, Tate G, Itoh K; et al. (2000). "A novel mutation of desert hedgehog in a patient with 46,XY partial gonadal dysgenesis accompanied by minifascicular neuropathy". Am. J. Hum. Genet. 67 (5): 1302–5. PMID 11017805.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bak M, Hansen C, Friis Henriksen K, Tommerup N (2001). "The human hedgehog-interacting protein gene: structure and chromosome mapping to 4q31.21-->q31.3". Cytogenet. Cell Genet. 92 (3–4): 300–3. PMID 11435703.CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hori Y, Gu X, Xie X, Kim SK (2006). "Differentiation of insulin-producing cells from human neural progenitor cells". PLoS Med. 2 (4): e103. doi:10.1371/journal.pmed.0020103. PMID 15839736.CS1 maint: Multiple names: authors list (link)
• Canto P, Vilchis F, Söderlund D; et al. (2006). "A heterozygous mutation in the desert hedgehog gene in patients with mixed gonadal dysgenesis". Mol. Hum. Reprod. 11 (11): 833–6. doi:10.1093/molehr/gah216. PMID 16390857.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)