Dixin is a protein that in humans is encoded by the DIXDC1gene.[1][2] When active it stops cancer metastasis due to extreme stickiness, both in vitro and in vivo.[3]
References
↑Katoh M, Katoh M (July 2003). "KIAA1735 gene on human chromosome 11q23.1 encodes a novel protein with myosine-tail homologous domain and C-terminal DIX domain". International Journal of Oncology. 23 (1): 145–50. doi:10.3892/ijo.23.1.145. PMID12792787.
Nagase T, Kikuno R, Hattori A, Kondo Y, Okumura K, Ohara O (December 2000). "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 7 (6): 347–55. doi:10.1093/dnares/7.6.347. PMID11214970.
Ohira M, Morohashi A, Inuzuka H, Shishikura T, Kawamoto T, Kageyama H, Nakamura Y, Isogai E, Takayasu H, Sakiyama S, Suzuki Y, Sugano S, Goto T, Sato S, Nakagawara A (August 2003). "Expression profiling and characterization of 4200 genes cloned from primary neuroblastomas: identification of 305 genes differentially expressed between favorable and unfavorable subsets". Oncogene. 22 (35): 5525–36. doi:10.1038/sj.onc.1206853. PMID12934113.
Wong CK, Luo W, Deng Y, Zou H, Ye Z, Lin SC (September 2004). "The DIX domain protein coiled-coil-DIX1 inhibits c-Jun N-terminal kinase activation by Axin and dishevelled through distinct mechanisms". The Journal of Biological Chemistry. 279 (38): 39366–73. doi:10.1074/jbc.M404598200. PMID15262978.