DMP1 (gene)

Dentin matrix acidic phosphoprotein
Identifiers
Symbols	DMP1 ;
External IDs	Template:OMIM5 Template:MGI HomoloGene: 68396
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Dentin matrix acidic phosphoprotein, also known as DMP1, is a human gene.

Dentin matrix acidic phosphoprotein is an extracellular matrix protein and a member of the small integrin binding ligand N-linked glycoprotein family. This protein, which is critical for proper mineralization of bone and dentin, is present in diverse cells of bone and tooth tissues. The protein contains a large number of acidic domains, multiple phosphorylation sites, a functional arg-gly-asp cell attachment sequence, and a DNA binding domain. In undifferentiated osteoblasts it is primarily a nuclear protein that regulates the expression of osteoblast-specific genes. During osteoblast maturation the protein becomes phosphorylated and is exported to the extracellular matrix, where it orchestrates mineralized matrix formation. Mutations in the gene are known to cause autosomal recessive hypophosphatemia, a disease that manifests as rickets and osteomalacia. The gene structure is conserved in mammals. Two transcript variants encoding different isoforms have been described for this gene.

Further reading

• George A, Sabsay B, Simonian PA, Veis A (1993). "Characterization of a novel dentin matrix acidic phosphoprotein. Implications for induction of biomineralization". J. Biol. Chem. 268 (17): 12624–30. PMID 8509401.CS1 maint: Multiple names: authors list (link)
• Aplin HM, Hirst KL, Crosby AH, Dixon MJ (1996). "Mapping of the human dentin matrix acidic phosphoprotein gene (DMP1) to the dentinogenesis imperfecta type II critical region at chromosome 4q21". Genomics. 30 (2): 347–9. doi:10.1006/geno.1995.9867. PMID 8586437.CS1 maint: Multiple names: authors list (link)
• Hillier LD, Lennon G, Becker M; et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags". Genome Res. 6 (9): 807–28. PMID 8889549.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hirst KL, Simmons D, Feng J; et al. (1997). "Elucidation of the sequence and the genomic organization of the human dentin matrix acidic phosphoprotein 1 (DMP1) gene: exclusion of the locus from a causative role in the pathogenesis of dentinogenesis imperfecta type II". Genomics. 42 (1): 38–45. doi:10.1006/geno.1997.4700. PMID 9177774.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Srinivasan R, Chen B, Gorski JP, George A (2000). "Recombinant expression and characterization of dentin matrix protein 1". Connect. Tissue Res. 40 (4): 251–8. PMID 10757113.CS1 maint: Multiple names: authors list (link)
• Kulkarni GV, Chen B, Malone JP; et al. (2000). "Promotion of selective cell attachment by the RGD sequence in dentine matrix protein 1". Arch. Oral Biol. 45 (6): 475–84. PMID 10775676.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Jain A, Karadag A, Fohr B; et al. (2002). "Three SIBLINGs (small integrin-binding ligand, N-linked glycoproteins) enhance factor H's cofactor activity enabling MCP-like cellular evasion of complement-mediated attack". J. Biol. Chem. 277 (16): 13700–8. doi:10.1074/jbc.M110757200. PMID 11825898.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Papagerakis P, Berdal A, Mesbah M; et al. (2002). "Investigation of osteocalcin, osteonectin, and dentin sialophosphoprotein in developing human teeth". Bone. 30 (2): 377–85. PMID 11856645.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Narayanan K, Ramachandran A, Hao J; et al. (2003). "Dual functional roles of dentin matrix protein 1. Implications in biomineralization and gene transcription by activation of intracellular Ca2+ store". J. Biol. Chem. 278 (19): 17500–8. doi:10.1074/jbc.M212700200. PMID 12615915.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chaplet M, De Leval L, Waltregny D; et al. (2004). "Dentin matrix protein 1 is expressed in human lung cancer". J. Bone Miner. Res. 18 (8): 1506–12. PMID 12929940.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Steiglitz BM, Ayala M, Narayanan K; et al. (2004). "Bone morphogenetic protein-1/Tolloid-like proteinases process dentin matrix protein-1". J. Biol. Chem. 279 (2): 980–6. doi:10.1074/jbc.M310179200. PMID 14578349.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Toyosawa S, Tomita Y, Kishino M; et al. (2004). "Expression of dentin matrix protein 1 in tumors causing oncogenic osteomalacia". Mod. Pathol. 17 (5): 573–8. doi:10.1038/modpathol.3800084. PMID 15001995.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chen S, Inozentseva-Clayton N, Dong J; et al. (2005). "Binding of two nuclear factors to a novel silencer element in human dentin matrix protein 1 (DMP1) promoter regulates the cell type-specific DMP1 gene expression". J. Cell. Biochem. 92 (2): 332–49. doi:10.1002/jcb.20051. PMID 15108359.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ogbureke KU, Fisher LW (2004). "Expression of SIBLINGs and their partner MMPs in salivary glands". J. Dent. Res. 83 (9): 664–70. PMID 15329369.
• Yang W, Lu Y, Kalajzic I; et al. (2005). "Dentin matrix protein 1 gene cis-regulation: use in osteocytes to characterize local responses to mechanical loading in vitro and in vivo". J. Biol. Chem. 280 (21): 20680–90. doi:10.1074/jbc.M500104200. PMID 15728181.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ogbureke KU, Fisher LW (2005). "Renal expression of SIBLING proteins and their partner matrix metalloproteinases (MMPs)". Kidney Int. 68 (1): 155–66. doi:10.1111/j.1523-1755.2005.00389.x. PMID 15954904.
• Ling Y, Rios HF, Myers ER; et al. (2006). "DMP1 depletion decreases bone mineralization in vivo: an FTIR imaging analysis". J. Bone Miner. Res. 20 (12): 2169–77. doi:10.1359/JBMR.050815. PMID 16294270.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Karadag A, Fedarko NS, Fisher LW (2006). "Dentin matrix protein 1 enhances invasion potential of colon cancer cells by bridging matrix metalloproteinase-9 to integrins and CD44". Cancer Res. 65 (24): 11545–52. doi:10.1158/0008-5472.CAN-05-2861. PMID 16357164.CS1 maint: Multiple names: authors list (link)
• Qin C, Huang B, Wygant JN; et al. (2006). "A chondroitin sulfate chain attached to the bone dentin matrix protein 1 NH2-terminal fragment". J. Biol. Chem. 281 (12): 8034–40. doi:10.1074/jbc.M512964200. PMID 16421105.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)