DOCK1

Dedicator of cytokinesis 1
Identifiers
Symbols	DOCK1 ; DOCK180; ced5
External IDs	Template:OMIM5 Template:MGI HomoloGene: 55575
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Dedicator of cytokinesis 1, also known as DOCK1, is a human gene.

This gene product binds to the SH3 domain of CRK protein. It may regulate cell surface extension and may have a role in the cell surface extension of an engulfing cell around a dying cell during apoptosis.

Further reading

• Hasegawa H, Kiyokawa E, Tanaka S; et al. (1996). "DOCK180, a major CRK-binding protein, alters cell morphology upon translocation to the cell membrane". Mol. Cell. Biol. 16 (4): 1770–6. PMID 8657152.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Takai S, Hasegawa H, Kiyokawa E; et al. (1996). "Chromosomal mapping of the gene encoding DOCK180, a major Crk-binding protein, to 10q26.13-q26.3 by fluorescence in situ hybridization". Genomics. 35 (2): 403–4. doi:10.1006/geno.1996.0378. PMID 8661160.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Matsuda M, Ota S, Tanimura R; et al. (1996). "Interaction between the amino-terminal SH3 domain of CRK and its natural target proteins". J. Biol. Chem. 271 (24): 14468–72. PMID 8662907.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Savill J (1998). "Apoptosis. Phagocytic docking without shocking". Nature. 392 (6675): 442–3. doi:10.1038/33025. PMID 9548247.
• Wu YC, Horvitz HR (1998). "C. elegans phagocytosis and cell-migration protein CED-5 is similar to human DOCK180". Nature. 392 (6675): 501–4. doi:10.1038/33163. PMID 9548255.
• Kiyokawa E, Hashimoto Y, Kobayashi S; et al. (1998). "Activation of Rac1 by a Crk SH3-binding protein, DOCK180". Genes Dev. 12 (21): 3331–6. PMID 9808620.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Albert ML, Kim JI, Birge RB (2001). "alphavbeta5 integrin recruits the CrkII-Dock180-rac1 complex for phagocytosis of apoptotic cells". Nat. Cell Biol. 2 (12): 899–905. doi:10.1038/35046549. PMID 11146654.CS1 maint: Multiple names: authors list (link)
• Kobayashi S, Shirai T, Kiyokawa E; et al. (2001). "Membrane recruitment of DOCK180 by binding to PtdIns(3,4,5)P3". Biochem. J. 354 (Pt 1): 73–8. PMID 11171081.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tu Y, Kucik DF, Wu C (2001). "Identification and kinetic analysis of the interaction between Nck-2 and DOCK180". FEBS Lett. 491 (3): 193–9. PMID 11240126.CS1 maint: Multiple names: authors list (link)
• Gu J, Sumida Y, Sanzen N, Sekiguchi K (2001). "Laminin-10/11 and fibronectin differentially regulate integrin-dependent Rho and Rac activation via p130(Cas)-CrkII-DOCK180 pathway". J. Biol. Chem. 276 (29): 27090–7. doi:10.1074/jbc.M102284200. PMID 11369773.CS1 maint: Multiple names: authors list (link)
• Gumienny TL, Brugnera E, Tosello-Trampont AC; et al. (2001). "CED-12/ELMO, a novel member of the CrkII/Dock180/Rac pathway, is required for phagocytosis and cell migration". Cell. 107 (1): 27–41. PMID 11595183.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zhou Z, Caron E, Hartwieg E; et al. (2001). "The C. elegans PH domain protein CED-12 regulates cytoskeletal reorganization via a Rho/Rac GTPase signaling pathway". Dev. Cell. 1 (4): 477–89. PMID 11703939.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Worby CA, Simonson-Leff N, Clemens JC; et al. (2002). "Drosophila Ack targets its substrate, the sorting nexin DSH3PX1, to a protein complex involved in axonal guidance". J. Biol. Chem. 277 (11): 9422–8. doi:10.1074/jbc.M110172200. PMID 11773052.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Brugnera E, Haney L, Grimsley C; et al. (2002). "Unconventional Rac-GEF activity is mediated through the Dock180-ELMO complex". Nat. Cell Biol. 4 (8): 574–82. doi:10.1038/ncb824. PMID 12134158.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Côté JF, Vuori K (2003). "Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity". J. Cell. Sci. 115 (Pt 24): 4901–13. PMID 12432077.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hsia DA, Mitra SK, Hauck CR; et al. (2003). "Differential regulation of cell motility and invasion by FAK". J. Cell Biol. 160 (5): 753–67. doi:10.1083/jcb.200212114. PMID 12615911.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Katoh H, Negishi M (2003). "RhoG activates Rac1 by direct interaction with the Dock180-binding protein Elmo". Nature. 424 (6947): 461–4. doi:10.1038/nature01817. PMID 12879077.
• Grimsley CM, Kinchen JM, Tosello-Trampont AC; et al. (2004). "Dock180 and ELMO1 proteins cooperate to promote evolutionarily conserved Rac-dependent cell migration". J. Biol. Chem. 279 (7): 6087–97. doi:10.1074/jbc.M307087200. PMID 14638695.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wang X, Wu YC, Fadok VA; et al. (2003). "Cell corpse engulfment mediated by C. elegans phosphatidylserine receptor through CED-5 and CED-12". Science. 302 (5650): 1563–6. doi:10.1126/science.1087641. PMID 14645848.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)