DOCK2

Dedicator of cytokinesis 2
Identifiers
Symbols	DOCK2 ; FLJ46592; KIAA0209
External IDs	Template:OMIM5 Template:MGI HomoloGene: 37984
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Dedicator of cytokinesis 2, also known as DOCK2, is a human gene.

The DOCK2 gene encodes a hematopoietic cell-specific CDM family protein that is indispensable for lymphocyte chemotaxis.[supplied by OMIM]

Further reading

• Reif K, Cyster J (2003). "The CDM protein DOCK2 in lymphocyte migration". Trends Cell Biol. 12 (8): 368–73. PMID 12191913.
• Nagase T, Seki N, Ishikawa K; et al. (1997). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain". DNA Res. 3 (5): 321–9, 341–54. PMID 9039502.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nishihara H, Kobayashi S, Hashimoto Y; et al. (1999). "Non-adherent cell-specific expression of DOCK2, a member of the human CDM-family proteins". Biochim. Biophys. Acta. 1452 (2): 179–87. PMID 10559471.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fukui Y, Hashimoto O, Sanui T; et al. (2001). "Haematopoietic cell-specific CDM family protein DOCK2 is essential for lymphocyte migration". Nature. 412 (6849): 826–31. doi:10.1038/35090591. PMID 11518968.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Brugnera E, Haney L, Grimsley C; et al. (2002). "Unconventional Rac-GEF activity is mediated through the Dock180-ELMO complex". Nat. Cell Biol. 4 (8): 574–82. doi:10.1038/ncb824. PMID 12134158.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nishihara H, Maeda M, Tsuda M; et al. (2002). "DOCK2 mediates T cell receptor-induced activation of Rac2 and IL-2 transcription". Biochem. Biophys. Res. Commun. 296 (3): 716–20. PMID 12176041.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nishihara H, Maeda M, Oda A; et al. (2003). "DOCK2 associates with CrkL and regulates Rac1 in human leukemia cell lines". Blood. 100 (12): 3968–74. doi:10.1182/blood-2001-11-0032. PMID 12393632.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Côté JF, Vuori K (2003). "Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity". J. Cell. Sci. 115 (Pt 24): 4901–13. PMID 12432077.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sanui T, Inayoshi A, Noda M; et al. (2003). "DOCK2 regulates Rac activation and cytoskeletal reorganization through interaction with ELMO1". Blood. 102 (8): 2948–50. doi:10.1182/blood-2003-01-0173. PMID 12829596.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Janardhan A, Swigut T, Hill B; et al. (2006). "HIV-1 Nef binds the DOCK2-ELMO1 complex to activate rac and inhibit lymphocyte chemotaxis". PLoS Biol. 2 (1): E6. doi:10.1371/journal.pbio.0020006. PMID 14737186.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Brill LM, Salomon AR, Ficarro SB; et al. (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry". Anal. Chem. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID 15144186.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rush J, Moritz A, Lee KA; et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lu M, Kinchen JM, Rossman KL; et al. (2005). "A Steric-inhibition model for regulation of nucleotide exchange via the Dock180 family of GEFs". Curr. Biol. 15 (4): 371–7. doi:10.1016/j.cub.2005.01.050. PMID 15723800.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• García-Bernal D, Sotillo-Mallo E, Nombela-Arrieta C; et al. (2007). "DOCK2 is required for chemokine-promoted human T lymphocyte adhesion under shear stress mediated by the integrin alpha4beta1". J. Immunol. 177 (8): 5215–25. PMID 17015707.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)