DOK1

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Identifiers
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External IDs	GeneCards: [1]
Orthologs
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	Wikidata
View/Edit Human

Docking protein 1 is a protein that in humans is encoded by the DOK1 gene.^[1]^[2]^[3]

Function

Docking protein 1 is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210(bcr/abl), a chimeric protein whose presence is associated with CML. Docking protein 1 contains a putative pleckstrin homology domain at the amino terminus and ten PXXP SH3 recognition motifs. Docking protein 2 binds p120 (RasGAP) from CML cells. It has been postulated to play a role in mitogenic signaling.^[4]

Interactions

DOK1 has been shown to interact with:

References

↑ Carpino N, Wisniewski D, Strife A, Marshak D, Kobayashi R, Stillman B, Clarkson B (February 1997). "p62(dok): a constitutively tyrosine-phosphorylated, GAP-associated protein in chronic myelogenous leukemia progenitor cells". Cell. 88 (2): 197–204. doi:10.1016/S0092-8674(00)81840-1. PMID 9008160.
↑ Nelms K, Snow AJ, Noben-Trauth K (December 1998). "Dok1 encoding p62(dok) maps to mouse chromosome 6 and human chromosome 2 in a region of translocation in chronic lymphocytic leukemia". Genomics. 53 (2): 243–5. doi:10.1006/geno.1998.5514. PMID 9790776.
↑ Ling Y, Maile LA, Badley-Clarke J, Clemmons DR (February 2005). "DOK1 mediates SHP-2 binding to the alphaVbeta3 integrin and thereby regulates insulin-like growth factor I signaling in cultured vascular smooth muscle cells". J. Biol. Chem. 280 (5): 3151–8. doi:10.1074/jbc.M411035200. PMID 15546884.
↑ "Entrez Gene: DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1)".
↑ ^5.0 ^5.1 ^5.2 ^5.3 van Dijk TB, van Den Akker E, Amelsvoort MP, Mano H, Löwenberg B, von Lindern M (November 2000). "Stem cell factor induces phosphatidylinositol 3'-kinase-dependent Lyn/Tec/Dok-1 complex formation in hematopoietic cells". Blood. 96 (10): 3406–13. PMID 11071635.
↑ ^6.0 ^6.1 Yamanashi Y, Baltimore D (January 1997). "Identification of the Abl- and rasGAP-associated 62 kDa protein as a docking protein, Dok". Cell. 88 (2): 205–11. doi:10.1016/s0092-8674(00)81841-3. PMID 9008161.
↑ ^7.0 ^7.1 ^7.2 Liang X, Wisniewski D, Strife A, Clarkson B, Resh MD (April 2002). "Phosphatidylinositol 3-kinase and Src family kinases are required for phosphorylation and membrane recruitment of Dok-1 in c-Kit signaling". J. Biol. Chem. 277 (16): 13732–8. doi:10.1074/jbc.M200277200. PMID 11825908.
↑ ^8.0 ^8.1 ^8.2 Dunant NM, Wisniewski D, Strife A, Clarkson B, Resh MD (May 2000). "The phosphatidylinositol polyphosphate 5-phosphatase SHIP1 associates with the dok1 phosphoprotein in bcr-Abl transformed cells". Cell. Signal. 12 (5): 317–26. doi:10.1016/s0898-6568(00)00073-5. PMID 10822173.
↑ Némorin JG, Duplay P (May 2000). "Evidence that Llck-mediated phosphorylation of p56dok and p62dok may play a role in CD2 signaling". J. Biol. Chem. 275 (19): 14590–7. doi:10.1074/jbc.275.19.14590. PMID 10799545.
↑ Murakami H, Yamamura Y, Shimono Y, Kawai K, Kurokawa K, Takahashi M (September 2002). "Role of Dok1 in cell signaling mediated by RET tyrosine kinase". J. Biol. Chem. 277 (36): 32781–90. doi:10.1074/jbc.M202336200. PMID 12087092.
↑ Sylla BS, Murphy K, Cahir-McFarland E, Lane WS, Mosialos G, Kieff E (June 2000). "The X-linked lymphoproliferative syndrome gene product SH2D1A associates with p62dok (Dok1) and activates NF-kappa B". Proc. Natl. Acad. Sci. U.S.A. 97 (13): 7470–5. doi:10.1073/pnas.130193097. PMC 16569. PMID 10852966.

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Wisniewski D, Strife A, Wojciechowicz D, Lambek C, Clarkson B (1994). "A 62-kilodalton tyrosine phosphoprotein constitutively present in primary chronic phase chronic myelogenous leukemia enriched lineage negative blast populations". Leukemia. 8 (4): 688–93. PMID 8152267.
Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
Yamanashi Y, Baltimore D (1997). "Identification of the Abl- and rasGAP-associated 62 kDa protein as a docking protein, Dok". Cell. 88 (2): 205–11. doi:10.1016/S0092-8674(00)81841-3. PMID 9008161.
Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
Vuica M, Desiderio S, Schneck JP (1997). "Differential effects of B cell receptor and B cell receptor-FcgammaRIIB1 engagement on docking of Csk to GTPase-activating protein (GAP)-associated p62". J. Exp. Med. 186 (2): 259–67. doi:10.1084/jem.186.2.259. PMC 2198989. PMID 9221755.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Chen M, She H, Davis EM, Spicer CM, Kim L, Ren R, Le Beau MM, Li W (1998). "Identification of Nck family genes, chromosomal localization, expression, and signaling specificity". J. Biol. Chem. 273 (39): 25171–8. doi:10.1074/jbc.273.39.25171. PMID 9737977.
Noguchi T, Matozaki T, Inagaki K, Tsuda M, Fukunaga K, Kitamura Y, Kitamura T, Shii K, Yamanashi Y, Kasuga M (1999). "Tyrosine phosphorylation of p62(Dok) induced by cell adhesion and insulin: possible role in cell migration". EMBO J. 18 (7): 1748–60. doi:10.1093/emboj/18.7.1748. PMC 1171261. PMID 10202139.
Cong F, Yuan B, Goff SP (1999). "Characterization of a novel member of the DOK family that binds and modulates Abl signaling". Mol. Cell. Biol. 19 (12): 8314–25. PMC 84915. PMID 10567556.
Berg KL, Siminovitch KA, Stanley ER (1999). "SHP-1 regulation of p62(DOK) tyrosine phosphorylation in macrophages". J. Biol. Chem. 274 (50): 35855–65. doi:10.1074/jbc.274.50.35855. PMID 10585470.
Becker E, Huynh-Do U, Holland S, Pawson T, Daniel TO, Skolnik EY (2000). "Nck-interacting Ste20 kinase couples Eph receptors to c-Jun N-terminal kinase and integrin activation". Mol. Cell. Biol. 20 (5): 1537–45. doi:10.1128/MCB.20.5.1537-1545.2000. PMC 85333. PMID 10669731.
Némorin JG, Duplay P (2000). "Evidence that Llck-mediated phosphorylation of p56dok and p62dok may play a role in CD2 signaling". J. Biol. Chem. 275 (19): 14590–7. doi:10.1074/jbc.275.19.14590. PMID 10799545.
Dunant NM, Wisniewski D, Strife A, Clarkson B, Resh MD (2000). "The phosphatidylinositol polyphosphate 5-phosphatase SHIP1 associates with the dok1 phosphoprotein in bcr-Abl transformed cells". Cell. Signal. 12 (5): 317–26. doi:10.1016/S0898-6568(00)00073-5. PMID 10822173.
Yoshida K, Yamashita Y, Miyazato A, Ohya K, Kitanaka A, Ikeda U, Shimada K, Yamanaka T, Ozawa K, Mano H (2000). "Mediation by the protein-tyrosine kinase Tec of signaling between the B cell antigen receptor and Dok-1". J. Biol. Chem. 275 (32): 24945–52. doi:10.1074/jbc.M909012199. PMID 10823839.
Sylla BS, Murphy K, Cahir-McFarland E, Lane WS, Mosialos G, Kieff E (2000). "The X-linked lymphoproliferative syndrome gene product SH2D1A associates with p62dok (Dok1) and activates NF-kappa B". Proc. Natl. Acad. Sci. U.S.A. 97 (13): 7470–5. doi:10.1073/pnas.130193097. PMC 16569. PMID 10852966.
Hubert P, Ferreira V, Debre P, Bismuth G (2000). "Molecular cloning of a truncated p62Dok1 isoform, p22Dok(del)". Eur. J. Immunogenet. 27 (3): 145–8. doi:10.1046/j.1365-2370.2000.00203.x. PMID 10940083.
Songyang Z, Yamanashi Y, Liu D, Baltimore D (2001). "Domain-dependent function of the rasGAP-binding protein p62Dok in cell signaling". J. Biol. Chem. 276 (4): 2459–65. doi:10.1074/jbc.M005504200. PMID 11042170.

[pmid9008160-1] Carpino N, Wisniewski D, Strife A, Marshak D, Kobayashi R, Stillman B, Clarkson B (February 1997). "p62(dok): a constitutively tyrosine-phosphorylated, GAP-associated protein in chronic myelogenous leukemia progenitor cells". Cell. 88 (2): 197–204. doi:10.1016/S0092-8674(00)81840-1. PMID 9008160.

[pmid9790776-2] Nelms K, Snow AJ, Noben-Trauth K (December 1998). "Dok1 encoding p62(dok) maps to mouse chromosome 6 and human chromosome 2 in a region of translocation in chronic lymphocytic leukemia". Genomics. 53 (2): 243–5. doi:10.1006/geno.1998.5514. PMID 9790776.

[pmid15546884-3] Ling Y, Maile LA, Badley-Clarke J, Clemmons DR (February 2005). "DOK1 mediates SHP-2 binding to the alphaVbeta3 integrin and thereby regulates insulin-like growth factor I signaling in cultured vascular smooth muscle cells". J. Biol. Chem. 280 (5): 3151–8. doi:10.1074/jbc.M411035200. PMID 15546884.

[entrez-4] "Entrez Gene: DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1)".

[pmid11071635-5] 5.0 ^5.1 ^5.2 ^5.3 van Dijk TB, van Den Akker E, Amelsvoort MP, Mano H, Löwenberg B, von Lindern M (November 2000). "Stem cell factor induces phosphatidylinositol 3'-kinase-dependent Lyn/Tec/Dok-1 complex formation in hematopoietic cells". Blood. 96 (10): 3406–13. PMID 11071635.

[pmid9008161-6] 6.0 ^6.1 Yamanashi Y, Baltimore D (January 1997). "Identification of the Abl- and rasGAP-associated 62 kDa protein as a docking protein, Dok". Cell. 88 (2): 205–11. doi:10.1016/s0092-8674(00)81841-3. PMID 9008161.

[pmid11825908-7] 7.0 ^7.1 ^7.2 Liang X, Wisniewski D, Strife A, Clarkson B, Resh MD (April 2002). "Phosphatidylinositol 3-kinase and Src family kinases are required for phosphorylation and membrane recruitment of Dok-1 in c-Kit signaling". J. Biol. Chem. 277 (16): 13732–8. doi:10.1074/jbc.M200277200. PMID 11825908.

[pmid10822173-8] 8.0 ^8.1 ^8.2 Dunant NM, Wisniewski D, Strife A, Clarkson B, Resh MD (May 2000). "The phosphatidylinositol polyphosphate 5-phosphatase SHIP1 associates with the dok1 phosphoprotein in bcr-Abl transformed cells". Cell. Signal. 12 (5): 317–26. doi:10.1016/s0898-6568(00)00073-5. PMID 10822173.

[pmid10799545-9] Némorin JG, Duplay P (May 2000). "Evidence that Llck-mediated phosphorylation of p56dok and p62dok may play a role in CD2 signaling". J. Biol. Chem. 275 (19): 14590–7. doi:10.1074/jbc.275.19.14590. PMID 10799545.

[pmid12087092-10] Murakami H, Yamamura Y, Shimono Y, Kawai K, Kurokawa K, Takahashi M (September 2002). "Role of Dok1 in cell signaling mediated by RET tyrosine kinase". J. Biol. Chem. 277 (36): 32781–90. doi:10.1074/jbc.M202336200. PMID 12087092.

[pmid10852966-11] Sylla BS, Murphy K, Cahir-McFarland E, Lane WS, Mosialos G, Kieff E (June 2000). "The X-linked lymphoproliferative syndrome gene product SH2D1A associates with p62dok (Dok1) and activates NF-kappa B". Proc. Natl. Acad. Sci. U.S.A. 97 (13): 7470–5. doi:10.1073/pnas.130193097. PMC 16569. PMID 10852966.

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DOK1

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Function

Interactions

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DOK1

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References

Further reading

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